Formulary
Maralixibat: Indications, Dosing, Side Effects and Interactions
Maralixibat is an inhibitor of the ileal bile acid transporter that acts locally in the ileum to reduce re-uptake of bile acids from the intestines into the...
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Maralixibat: Indications, Dosing, Side Effects and Interactions
Maralixibat is an inhibitor of the ileal bile acid transporter that acts locally in the ileum to reduce re-uptake of bile acids from the intestines into the...
Drug action
Maralixibat is an inhibitor of the ileal bile acid transporter that acts locally in the ileum to reduce re-uptake of bile acids from the intestines into the liver, thereby preventing their accumulation.
Indications and dose
**Cholestatic pruritus [associated with Alagille syndrome] (under expert supervision)**
- **Adult** (By Mouth): Initially 190 micrograms/kg once daily (max. per dose 14.25 mg) for 7 days, dose to be taken up to 30 minutes before or with a meal in the morning, then increased to 380 micrograms/kg once daily (max. per dose 28.5 mg), dose to be taken up to 30 minutes before or with a meal in the morning, reduce dose to 190 micrograms/kg once daily or interrupt treatment if poor tolerability; consider alternative treatment if no benefit after 3 months.
**Cholestatic pruritus [associated with Alagille syndrome] (under expert supervision) for maralixibat**
- **Child 2 months-17 years** (By mouth): Initially 190 micrograms/kg once daily (max. per dose 14.25 mg) for 7 days, dose to be taken up to 30 minutes before or with a meal in the morning, then increased to 380 micrograms/kg once daily (max. per dose 28.5 mg), dose to be taken up to 30 minutes before or with a meal in the morning, reduce dose to 190 micrograms/kg once daily or interrupt treatment if poor tolerability; consider alternative treatment if no benefit after 3 months.
Side effects
Common or very common Abdominal pain; diarrhoea
Pregnancy
Avoid (no information available). M
Breast feeding
Present in milk but amount probably too small to be harmful M (recommendation also supported by tertiary sources).
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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