Formulary
Lopinavir with ritonavir: Indications, Dosing, Side Effects and Interactions
Lopinavir with ritonavir clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Lopinavir with ritonavir: Indications, Dosing, Side Effects and Interactions
Lopinavir with ritonavir clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**HIV infection in combination with other antiretroviral drugs**
- **Adult** (By Mouth Using Tablets): 400/100 mg twice daily, alternatively 800/200 mg once daily, once daily dose to be used only in adults with a HIV strain that has less than 3 mutations to protease inhibitors.
- **Adult** (By Mouth Using Oral Solution): 5 mL twice daily.
**HIV infection in combination with other antiretroviral drugs for lopinavir with ritonavir**
- **Child 2-17 years (body-weight up to 40 kg and body surface area 0.5-0.7 m2)** (By mouth using tablets): 200/50 mg twice daily.
- **Child 2-17 years (body-weight up to 40 kg and body surface area 0.8-1.1 m2)** (By mouth using tablets): 300/75 mg twice daily.
- **Child 2-17 years (body-weight 40 kg and above and body surface area 1.2 m2 and above)** (By mouth using tablets): 400/100 mg twice daily.
- **Child 14 days-5 months** (By mouth using oral solution): 3.75 mL/m2 twice daily.
- **Child 6 months-17 years** (By mouth using oral solution): 2.9 mL/m2 twice daily (max. per dose 5 mL).
Cautions
For all protease inhibitors Haemophilia (increased risk of bleeding) Cautions For lopinavir with ritonavir Cardiac conduction disorders; pancreatitis; patients at high risk of cardiovascular disease; structural heart disease
Contraindications
For all protease inhibitors Acute porphyrias
Side effects
For all protease inhibitors Common or very common Angioedema; anxiety; appetite abnormal; arthralgia; asthenia; diabetes mellitus; diarrhoea; dizziness; dyslipidaemia; fever; gastrointestinal discomfort; gastrointestinal disorders; headache; hepatic disorders; hypersensitivity; hypertension; myalgia; nausea; oral ulceration; pancreatitis; peripheral neuropathy; seizure; skin reactions; sleep disorders; syncope; taste altered; urinary frequency increased; vomiting Uncommon Alopecia; dry mouth; immune reconstitution inflammatory syndrome; myocardial infarction; osteonecrosis; weight increased Rare or very rare Stevens-Johnson syndrome Side-effects For lopinavir with ritonavir Common or very common Anaemia; increased risk of infection; leucopenia; lymphadenopathy; menstrual cycle irregularities; migraine; muscle spasms; muscle weakness; myopathy; neutropenia; night sweats; pain; sexual dysfunction Uncommon Atherosclerosis; atrioventricular block; cholangitis; constipation; deep vein thrombosis; haemorrhage; hyperbilirubinaemia; hypogonadism; nephritis; stomatitis; stroke; tinnitus; tremor; tricuspid valve incompetence; vasculitis; vertigo; visual impairment Side-effects, further information Signs and symptoms suggestive of pancreatitis (including raised serum lipase) should be evaluated-discontinue if pancreatitis diagnosed.
Pregnancy
For lopinavir with ritonavir For tablets , manufacturer advises only use if potential benefit outweighs risk-toxicity in animal studies (recommendation also supported by specialist sources). Avoid oral solution due to high alcohol and propylene glycol content.
Hepatic impairment
For all protease inhibitors In general, manufacturers advise use with caution in patients with chronic hepatitis B or C (increased risk of hepatic side-effects). Hepatic impairment For lopinavir with ritonavir For oral solution , manufacturer advises avoid due to propylene glycol content (risk of toxicity). For tablets , manufacturer advises avoid in severe impairment (no information available).
Renal impairment
For lopinavir with ritonavir Avoid oral solution due to high propylene glycol content. M
Medicinal forms
Tablet,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Lopinavir with ritonavir in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

