Formulary
Lofexidine hydrochloride: Indications, Dosing, Side Effects and Interactions
Lofexidine is an alpha 2 -adrenergic agonist.
MedNext Academy | 3 min read
Lofexidine hydrochloride: Indications, Dosing, Side Effects and Interactions
Lofexidine is an alpha 2 -adrenergic agonist.
Drug action
Lofexidine is an alpha 2 -adrenergic agonist.
Indications and dose
**Management of symptoms of opioid withdrawal**
- **Adult** (By Mouth): Initially 800 micrograms daily in divided doses, increased in steps of 400-800 micrograms daily (max. per dose 800 micrograms) as required recommended duration of treatment 7-10 days if no opioid use (but longer may be required); maximum 2.4 mg per day.
Cautions
Bradycardia; cerebrovascular disease; depression; hypotension (monitor pulse rate and blood pressure); metabolic disturbances; recent myocardial infarction; risk factors for QT interval prolongation; severe coronary insufficiency
Side effects
Common or very common Bradycardia; dizziness; drowsiness; hypotension; mucosal dryness Frequency not known QT interval prolongation
Pregnancy
Use only if benefit outweighs risk-no information available.
Breast feeding
Use only if benefit outweighs risk-no information available.
Renal impairment
Caution in chronic impairment.
Medicinal forms
Medicinal forms No licensed medicines listed.
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Lofexidine hydrochloride in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

