Formulary
Lixisenatide: Indications, Dosing, Side Effects and Interactions
Binds to, and activates, the GLP-1 (glucagon-like peptide-1) receptor to increase insulin secretion, suppresses glucagon secretion, and slows gastric emptying.
MedNext Academy | 3 min read
Lixisenatide: Indications, Dosing, Side Effects and Interactions
Binds to, and activates, the GLP-1 (glucagon-like peptide-1) receptor to increase insulin secretion, suppresses glucagon secretion, and slows gastric emptying.
Drug action
Binds to, and activates, the GLP-1 (glucagon-like peptide-1) receptor to increase insulin secretion, suppresses glucagon secretion, and slows gastric emptying.
Indications and dose
**Type 2 diabetes mellitus in combination with other antidiabetic drugs (including insulin) if existing treatment fails to achieve adequate glycaemic control**
- **Adult** (By Subcutaneous Injection): Initially 10 micrograms once daily for 14 days, then increased to 20 micrograms once daily, dose to be taken within 1 hour before a meal.
Cautions
General anaesthesia or deep sedation (risk of pulmonary aspiration due to delayed gastric emptying); history of pancreatitis
Contraindications
Ketoacidosis; severe gastro-intestinal disease
Side effects
Common or very common Back pain; cystitis; diarrhoea; dizziness; drowsiness; dyspepsia; headache; increased risk of infection; nausea; vomiting Uncommon Gallbladder disorders; urticaria Rare or very rare Impaired gastric emptying Frequency not known Arrhythmia; pancreatitis acute Side-effects, further information Discontinue if symptoms of acute pancreatitis occur, such as persistent, severe abdominal pain. If pancreatitis confirmed, do not restart treatment.
Pregnancy
Avoid-toxicity in animal studies.
Breast feeding
Avoid-no information available.
Renal impairment
Avoid if creatinine clearance less than 30 mL/minute (no information available). M See Prescribing in renal impairment .
Medicinal forms
Medicinal forms No licensed medicines listed.
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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