Formulary
Lisdexamfetamine mesilate: Indications, Dosing, Side Effects and Interactions
Lisdexamfetamine is a prodrug of dexamfetamine.
MedNext Academy | 3 min read
Lisdexamfetamine mesilate: Indications, Dosing, Side Effects and Interactions
Lisdexamfetamine is a prodrug of dexamfetamine.
Drug action
Lisdexamfetamine is a prodrug of dexamfetamine.
Indications and dose
**Attention deficit hyperactivity disorder (initiated by a specialist)**
- **Child** (By Mouth): 6-17 years Initially 30 mg once daily, alternatively initially 20 mg once daily, increased in steps of 10-20 mg every week if required, dose to be taken in the morning, discontinue if response insufficient after 1 month; maximum 70 mg per day.
- **Adult** (By Mouth): Initially 30 mg once daily, increased in steps of 20 mg every week if required, dose to be taken in the morning, discontinue if response insufficient after 1 month; maximum 70 mg per day.
**Attention deficit hyperactivity disorder (initiated by a specialist) for lisdexamfetamine mesilate**
- **Child 6-17 years** (By mouth): Initially 30 mg once daily, alternatively initially 20 mg once daily, increased in steps of 10-20 mg every week if required, dose to be taken in the morning, discontinue if response insufficient after 1 month; maximum 70 mg per day.
Cautions
Bipolar disorder; history of cardiovascular disease; history of substance abuse; may lower seizure threshold (discontinue if seizures occur); psychotic disorders; susceptibility to angle-closure glaucoma; tics; Tourette syndrome Cautions, further information Cardiovascular disease Manufacturer advises caution in patients with underlying conditions that might be compromised by increases in blood pressure or heart rate; see also Contra-indications .
Contraindications
Advanced arteriosclerosis; agitated states; hyperthyroidism; moderate hypertension; severe hypertension; symptomatic cardiovascular disease
Side effects
Common or very common Abdominal pain upper; anxiety; appetite decreased; behaviour abnormal; constipation; diarrhoea; dizziness; dry mouth; dyspnoea; fatigue; feeling jittery; headache; hyperhidrosis (uncommon in children); insomnia; mood altered; movement disorders (uncommon in children); nausea; palpitations; sexual dysfunction (uncommon in children); tachycardia; tremor; weight decreased Uncommon Depression (very common in children); drowsiness (very common in children); fever (very common in children); logorrhea; psychiatric disorders (very common in children); skin reactions (very common in children); taste altered; vision blurred; vomiting (very common in children) Frequency not known Angioedema; cardiomyopathy (uncommon in children); drug dependence; hallucination (uncommon in children); hepatitis allergic; mydriasis (uncommon in children); psychotic disorder; Raynaud's phenomenon (uncommon in children); seizure; Stevens-Johnson syndrome Overdose Amfetamines cause wakefulness, excessive activity, paranoia, hallucinations, and hypertension followed by exhaustion, convulsions, hyperthermia, and coma. See Stimulants under Emergency treatment of poisoning .
Pregnancy
Manufacturer advises use only if potential benefit outweighs risk.
Breast feeding
Manufacturer advises avoid-present in human milk.
Renal impairment
Dose adjustments Manufacturer advises max. dose 50 mg daily in severe impairment.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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