Formulary
Linaclotide: Indications, Dosing, Side Effects and Interactions
Linaclotide clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Linaclotide: Indications, Dosing, Side Effects and Interactions
Linaclotide clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Moderate to severe irritable bowel syndrome with constipation**
- **Adult** (By Mouth): 290 micrograms once daily, dose to be taken at least 30 minutes before meals, review treatment if no response after 4 weeks.
Cautions
Predisposition to fluid and electrolyte disturbances
Contraindications
Gastro-intestinal obstruction; inflammatory bowel disease
Side effects
Common or very common Diarrhoea; dizziness; gastrointestinal discomfort; gastrointestinal disorders Uncommon Appetite decreased; dehydration; haemorrhage; hypokalaemia; nausea; postural hypotension; vomiting Frequency not known Rash Side-effects, further information Manufacturer advises if diarrhoea severe or prolonged, consider suspending treatment.
Interactions
**Other interactions (3):**
- Linaclotide is rarely detectable in plasma following administration of the recommended clinical doses and in vitro studies have shown that linaclotide is neither a substrate nor an inhibitor/inducer...
- A food interaction clinical study in healthy subjects showed that linaclotide was not detectable in plasma either in fed or in fasted conditions at the therapeutic doses.
- Concomitant treatment with proton pump inhibitors, laxatives or NSAIDs may increase the risk of diarrhoea.
Pregnancy
Manufacturer advises avoid.
Breast feeding
Unlikely to be present in milk in significant amounts, but manufacturer advises avoid.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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