Formulary
Lauromacrogol 400: Indications, Dosing, Side Effects and Interactions
Lauromacrogol 400 clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Lauromacrogol 400: Indications, Dosing, Side Effects and Interactions
Lauromacrogol 400 clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Sclerotherapy of varicose veins in legs**
- **Adult** (By Intravenous Injection): (consult product literature).
Cautions
Asymptomatic patent foramen ovale (use smaller volumes and avoid Valsalva manoeuvre immediately after administration); extravasation may cause necrosis of tissues; leg oedema; microangiopathy or neuropathy; occlusive arterial disease (when treating telangiectasias); previous visual or neurological symptoms, e.g. migraine, with foam sclerotherapy (use smaller volumes and avoid Valsalva manoeuvre immediately after administration); reduced mobility; resuscitation facilities must be available
Contraindications
Asthma; blood disorders; high risk of thrombosis; hyperthyroidism; inability to walk; neoplasm; respiratory disease; severe occlusive arterial disease; skin disease; symptomatic right-to-left shunt e.g. patent foramen ovale (if administered as foam); systemic infection; thromboembolism; uncontrolled diabetes mellitus
Side effects
Common or very common Haematoma; neovascularisation; skin reactions Uncommon Embolism and thrombosis; induration; nerve injury; soft tissue necrosis; swelling Rare or very rare Angioedema; aphasia; arrhythmias; asthenia; asthma; ataxia; cardiac arrest; cerebrovascular insufficiency; chest discomfort; circulatory collapse; confusion; cough; dizziness; dyspnoea; fever; headaches; hemiparesis; hot flush; loss of consciousness; malaise; nausea; oral hypoaesthesia; pain in extremity; palpitations; paraesthesia; stress cardiomyopathy; syncope; taste altered; vasculitis; visual impairment; vomiting
Pregnancy
Avoid unless potential benefit outweighs risk-toxicity in animal studies. M
Breast feeding
Specialist sources indicate probably suitable for use-unlikely to be excreted into milk.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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