Formulary
Japanese encephalitis vaccine: Indications, Dosing, Side Effects and Interactions
For japanese encephalitis vaccine Japanese encephalitis vaccine is an inactivated vaccine containing adsorbed Japanese encephalitis virus.
MedNext Academy | 4 min read
Japanese encephalitis vaccine: Indications, Dosing, Side Effects and Interactions
For japanese encephalitis vaccine Japanese encephalitis vaccine is an inactivated vaccine containing adsorbed Japanese encephalitis virus.
Drug action
For japanese encephalitis vaccine Japanese encephalitis vaccine is an inactivated vaccine containing adsorbed Japanese encephalitis virus.
Indications and dose
**Immunisation against Japanese encephalitis**
- **Child** (By Intramuscular Injection): 3-17 years 0.5 mL every 28 days for 2 doses, alternatively 0.5 mL every 7 days for 2 doses, deltoid muscle is preferred site in older children, immunisation should be completed at least 1 week before potential exposure.
- **Adult** (By Intramuscular Injection): 0.5 mL every 28 days for 2 doses, alternatively 0.5 mL every 7 days for 2 doses, deltoid muscle is preferred site of injection, immunisation should be completed at least 1 week before potential exposure.
**First booster**
- **Adult** (By Intramuscular Injection): 0.5 mL after 1-2 years, deltoid muscle is preferred site of injection, for those at continued risk, the booster dose should be given 1 year after completing the primary course.
- **Elderly** (By Intramuscular Injection): 0.5 mL after 1 year, for those at continued risk, deltoid muscle is preferred site of injection.
**Second booster**
- **Adult** (By Intramuscular Injection): 0.5 mL after 10 years, for those at continued risk, deltoid muscle is preferred site of injection.
**Immunisation against Japanese encephalitis for japanese encephalitis vaccine**
- **Child 2-35 months** (By intramuscular injection): 0.25 mL every 28 days for 2 doses, alternatively 0.25 mL every 7 days for 2 doses, anterolateral thigh may be used as the injection site in infants; deltoid muscle is preferred site in older children, immunisation should be completed at least 1 week before potential exposure.
- **Child 3-17 years** (By intramuscular injection): 0.5 mL every 28 days for 2 doses, alternatively 0.5 mL every 7 days for 2 doses, deltoid muscle is preferred site in older children, immunisation should be completed at least 1 week before potential exposure.
**First booster for japanese encephalitis vaccine**
- **Child 14-35 months** (By intramuscular injection): 0.25 mL after 1-2 years, anterolateral thigh may be used as the injection site in infants; deltoid muscle is preferred site in older children, for those at continued risk, the booster dose should be given 1 year after completing the primary course.
- **Child 3-17 years** (By intramuscular injection): 0.5 mL after 1-2 years, deltoid muscle is preferred site in older children, for those at continued risk, the booster dose should be given 1 year after completing the primary course.
Cautions
For all vaccines, general Acute illness; minor illnesses Cautions, further information Illness UKHSA advises vaccination may be postponed if the individual is suffering from an acute illness; however, it is not necessary to postpone immunisation in patients with minor illnesses without fever or systemic upset. Predisposition to neurological problems UKHSA advises: when there is a personal or family history of febrile convulsions, there is an increased risk of these occurring during fever from any cause including immunisation, but this is not a contra-indication to immunisation. In children who have had a seizure associated with fever without neurological deterioration, immunisation is recommended ; advice on the management of fever should be given before immunisation. When a child has had a convulsion not associated with fever, and the neurological condition is not deteriorating, immunisation is recommended ; children with stable neurological disorders (e.g. spina bifida, congenital brain abnormality, and peri-natal hypoxic-ischaemic encephalopathy) should be immunised according to the recommended schedule; when there is a still evolving neurological problem , including poorly controlled epilepsy, immunisation should be deferred and the child referred to a specialist. Immunisation is recommended if a cause for the neurological disorder is identified. If a cause is not identified, immunisation should be deferred until the condition is stable. Impaired immune response and drugs affecting immune response Immune response to vaccines may be reduced in immunosuppressed patients, UKHSA advises consider seeking specialist advice.
Side effects
For all vaccines, general Common or very common Abdominal pain; appetite decreased; arthralgia; diarrhoea; dizziness; fatigue; fever; headache; lymphadenopathy; malaise; myalgia; nausea; skin reactions; vomiting Uncommon Hypersensitivity Side-effects For japanese encephalitis vaccine Common or very common Influenza like illness (frequency not known in children) Uncommon Asthenia (in adults); chills (in adults); hyperhidrosis (in adults); migraine (in adults); musculoskeletal stiffness (in adults); vertigo (in adults) Rare or very rare Dyspnoea (in adults); eyelid oedema (in adults); neuritis (in adults); pain in extremity (in adults); palpitations (in adults); paraesthesia (in adults); peripheral oedema (in adults); tachycardia (in adults); taste altered (in adults); thrombocytopenia (in adults) Frequency not known Cough (in children); irritability (in children)
Pregnancy
For japanese encephalitis vaccine Although manufacturer advises avoid because of limited information, miscarriage has been associated with Japanese encephalitis virus infection acquired during the first 2 trimesters of pregnancy.
Medicinal forms
Solution,Injection
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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