Formulary
Insulin aspart: Indications, Dosing, Side Effects and Interactions
Insulin aspart is a recombinant human insulin analogue with a rapid onset and short duration of action.
MedNext Academy | 3 min read
Insulin aspart: Indications, Dosing, Side Effects and Interactions
Insulin aspart is a recombinant human insulin analogue with a rapid onset and short duration of action.
Drug action
Insulin aspart is a recombinant human insulin analogue with a rapid onset and short duration of action.
Indications and dose
**Diabetes mellitus**
- **Child** (By Subcutaneous Injection): Administer immediately before meals or when necessary shortly after meals, according to requirements.
- **Adult** (By Subcutaneous Injection): Administer immediately before meals or when necessary shortly after meals, according to requirements.
- **Child** (By Subcutaneous Infusion, Or By Intravenous Infusion): According to requirements.
- **Adult** (By Subcutaneous Infusion, Or By Intravenous Infusion): According to requirements.
**Diabetes mellitus for Fiasp**
- **Child 1-17 years** (By subcutaneous injection): Administer immediately before meals or when necessary shortly after meals, according to requirements.
- **Child 1-17 years** (By subcutaneous infusion, or by intravenous infusion): According to requirements.
**Diabetes mellitus for Novorapid**
- **Child** (By subcutaneous injection): Administer immediately before meals or when necessary shortly after meals, according to requirements.
- **Child** (By subcutaneous infusion, or by intravenous infusion): According to requirements.
Side effects
Common or very common Oedema Uncommon Lipodystrophy Frequency not known Cutaneous amyloidosis Overdose Overdose causes hypoglycaemia. Side-effects For insulin aspart Common or very common Skin reactions Uncommon Refraction disorder
Interactions
**Other interactions (5):**
- A number of medicinal products are known to interact with the glucose metabolism.
- The following substances may reduce insulin requirement: Oral antidiabetics, monoamine oxidase inhibitors (MAOIs), beta-blockers, angiotensin converting enzyme (ACE) inhibitors, salicylates,...
- The following substances may increase insulin requirement: Oral contraceptives, thiazides, glucocorticoids, thyroid hormones, sympathomimetics, growth hormone and danazol.
- Octreotide/lanreotide may either increase or decrease the insulin requirement.
- Alcohol may intensify or reduce the hypoglycaemic effect of insulin.
Pregnancy
During pregnancy, insulin requirements may alter and doses should be assessed frequently by an experienced diabetes physician. The dose of insulin generally needs to be increased in the second and third trimesters of pregnancy. Pregnancy For insulin aspart Not known to be harmful-may be used during pregnancy.
Breast feeding
During breast-feeding, insulin requirements may alter and doses should be assessed frequently by an experienced diabetes physician. Breast feeding For insulin aspart Not known to be harmful-may be used during lactation.
Hepatic impairment
Insulin requirements may be decreased.
Renal impairment
The compensatory response to hypoglycaemia is impaired in renal impairment. Dose adjustments Insulin requirements may decrease in patients with renal impairment and therefore dose reduction may be necessary. M
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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