Formulary
Inclisiran: Indications, Dosing, Side Effects and Interactions
Inclisiran is a small interfering RNA which limits production of PCSK9, increasing uptake of LDL-cholesterol and thereby lowering levels in blood.
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Inclisiran: Indications, Dosing, Side Effects and Interactions
Inclisiran is a small interfering RNA which limits production of PCSK9, increasing uptake of LDL-cholesterol and thereby lowering levels in blood.
Drug action
Inclisiran is a small interfering RNA which limits production of PCSK9, increasing uptake of LDL-cholesterol and thereby lowering levels in blood.
Indications and dose
**Primary hypercholesterolaemia or mixed dyslipidaemia [in combination with a statin, or with a statin and other lipid-lowering therapies, or with other lipid-lowering therapies or alone if a statin contra-indicated or not tolerated]**
- **Adult** (By Subcutaneous Injection): Initially 284 mg for 1 dose, followed by 284 mg after 3 months for 1 dose, then 284 mg every 6 months.
Pregnancy
Avoid-no information available. M
Breast feeding
Avoid-no information available. M
Hepatic impairment
Caution in severe impairment-no information available. M
Renal impairment
Caution in severe impairment-no information available. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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