Formulary
Imipenem with cilastatin and relebactam: Indications, Dosing, Side Effects and Interactions
Imipenem with cilastatin and relebactam clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Imipenem with cilastatin and relebactam: Indications, Dosing, Side Effects and Interactions
Imipenem with cilastatin and relebactam clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Aerobic Gram-negative infections [in patients with limited treatment options] (administered on expert advice)**
- **Adult** (By Intravenous Infusion): 500 mg every 6 hours, duration should be tailored to site of infection-consult product literature.
Cautions
For imipenem with cilastatin and relebactam Neutropenia (consider alternative treatment options); severe infections (consider alternative treatment options); supra-normal creatinine clearance Cautions, further information Supra-normal creatinine clearance Manufacturer advises the usual dose may not be sufficient to treat patients with creatinine clearance 150 mL/minute or more, and alternative treatment options should be considered.
Renal impairment
For imipenem with cilastatin and relebactam Manufacturer advises caution if creatinine clearance less than 90 mL/minute. Dose adjustments Manufacturer advises reduce dose if creatinine clearance less than 90 mL/minute-consult product literature. See Prescribing in renal impairment .
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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