Formulary
Idarucizumab: Indications, Dosing, Side Effects and Interactions
Idarucizumab is a humanised monoclonal antibody fragment that binds specifically to dabigatran and its metabolites, thereby reversing the anticoagulant effect.
MedNext Academy | 3 min read
Idarucizumab: Indications, Dosing, Side Effects and Interactions
Idarucizumab is a humanised monoclonal antibody fragment that binds specifically to dabigatran and its metabolites, thereby reversing the anticoagulant effect.
Drug action
Idarucizumab is a humanised monoclonal antibody fragment that binds specifically to dabigatran and its metabolites, thereby reversing the anticoagulant effect.
Indications and dose
**Rapid reversal of dabigatran**
- **Adult** (By Intravenous Injection, Or By Intravenous Infusion): for emergency procedures, or in life-threatening or uncontrolled bleeding (specialist supervision in hospital) 5 g, followed by 5 g if required.
Cautions
Risk of thrombosis Cautions, further information Manufacturer advises to consider re-starting anticoagulant therapy as soon as medically appropriate to reduce the risk of thrombosis. Dabigatran can be re-started 24 hours after administration of idarucizumab; other anticoagulant therapy can be started at any time.
Interactions
**Other interactions (2):**
- Preclinical investigations with idarucizumab have shown no interactions with volume expanders.
- Thus idarucizumab will not reverse the effects of other anticoagulants.
Pregnancy
Manufacturer advises use only if potential benefit outweighs risk-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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