Formulary
Hyaluronidase: Indications, Dosing, Side Effects and Interactions
Hyaluronidase clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Hyaluronidase: Indications, Dosing, Side Effects and Interactions
Hyaluronidase clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Enhance permeation of subcutaneous or intramuscular injections**
- **Adult** (By Subcutaneous Injection, Or By Intramuscular Injection): 1500 units, to be dissolved directly into the solution to be injected (ensure compatibility).
**Enhance permeation of ophthalmic local anaesthetic**
- **Adult** (To The Eye): 15 units/mL, to be mixed with the local anaesthetic solution.
**Hypodermoclysis**
- **Adult** (By Subcutaneous Injection): 1500 units, to be dissolved in 1 mL water for injections or 0.9% sodium chloride injection, administered before start of 500-1000 mL infusion fluid.
**Extravasation for hyaluronidase**
- **Child** (By local infiltration): (consult product literature).
Cautions
When used for hypodermoclysis Elderly (control speed and total volume and avoid overhydration especially in renal impairment)
Contraindications
Avoid sites where infection is present; avoid sites where malignancy is present; do not apply direct to cornea; not for anaesthesia in unexplained premature labour; not for intravenous administration; not to be used to enhance the absorption and dispersion of dopamine and/or alpha-adrenoceptor agonists; not to be used to reduce swelling of bites; not to be used to reduce swelling of stings
Side effects
Frequency not known Oedema; periorbital oedema
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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