Formulary
Glycerol: Indications, Dosing, Side Effects and Interactions
Glycerol clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Glycerol: Indications, Dosing, Side Effects and Interactions
Glycerol clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Constipation**
- **Child** (By Rectum): 12-17 years 4 g as required.
- **Adult** (By Rectum): 4 g as required.
**Constipation for glycerol**
- **Child 1-11 months** (By rectum): 1 g as required.
- **Child 1-11 years** (By rectum): 2 g as required.
- **Child 12-17 years** (By rectum): 4 g as required.
Interactions
**Other interactions (8):**
- Concomitant use of medicinal products known to inhibit lipase should be given with caution as glycerol phenylbutyrate is hydrolysed by digestive lipase into phenylbutyrate acid and glycerol.
- Glycerol phenylbutyrate and/or its metabolites, PAA and PBA, have been shown to be weak inducers of CYP3A4 enzyme in vivo .
- In vivo exposure to glycerol phenylbutyrate has resulted in decreased systemic exposure to midazolam of approximately 32% and increased exposure to the 1-hydroxy metabolite of midazolam, suggesting...
- The potential for interaction of glycerol phenylbutyrate as a CYP3A4 inducer and those products predominantly metabolised by the CYP3A4 pathway is possible.
- Therefore, therapeutic effects and/or metabolite levels of medicinal products, including some oral contraceptives that are substrates for this enzyme may be reduced and their full effects cannot be...
- The effects of glycerol phenylbutyrate on cytochrome P450 (CYP) 2C9 isoenzyme and potential for interaction with celecoxib has been studied in humans with no evidence of an interaction observed.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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