Formulary
Glucose: Indications, Dosing, Side Effects and Interactions
Glucose clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 5 min read
Glucose: Indications, Dosing, Side Effects and Interactions
Glucose clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Establish presence of gestational diabetes**
- **Adult** (By Mouth): Test dose 75 g, anhydrous glucose to be given to the fasting patient and blood-glucose concentrations measured at intervals, to be given with 200-300 mL fluid.
**Oral glucose tolerance test**
- **Adult** (By Mouth): Test dose 75 g, anhydrous glucose to be given to the fasting patient and blood-glucose concentrations measured at intervals, to be given with 200-300 mL fluid.
**Hypoglycaemia**
- **Child** (By Mouth): 12-17 years 15 g, repeated after 15 minutes if necessary, 15 g is 5 tubes of glucose 40% oral gel. If oral glucose formulations are not available, the dose may be given using another fast-acting carbohydrate; 15 g is
- **Adult** (By Mouth): 15-20 g, repeated after 15 minutes if necessary, 15-20 g is 5-2 tubes of glucose 40% oral gel. If oral glucose formulations are not available, the dose may be given using another fast-acting carbohydrate; 15-20 g is
- **Child** (By Intravenous Infusion): 500 mg/kg, to be administered as Glucose 10% intravenous infusion into a large vein through a large-gauge needle; care is required since this concentration is irritant.
- **Adult** (By Intravenous Infusion): 15-20 g, to be administered over 15 minutes as Glucose 10% or 20% intravenous infusion into a large vein through a large-gauge needle; care is required since these concentrations are irritant.
**Energy source**
- **Adult** (By Intravenous Infusion): 1-3 litres daily, solution concentration of 20-50% to be administered.
**Fluid and carbohydrate replacement**
- **Adult** (By Intravenous Infusion): The volume of glucose solution needed to replace deficits may vary (consult product literature).
**Persistent cyanosis (in combination with propranolol) when blood glucose less than 3 mmol/litre (followed by morphine)**
- **Child** (By Intravenous Infusion): 200 mg/kg, to be administered as Glucose 10% intravenous infusion over 10 minutes.
**Diabetic ketoacidosis**
- **Adult** (By Intravenous Infusion): (consult local protocol).
**Establish presence of gestational diabetes for glucose**
- **Child** (By mouth): Test dose 75 g, anhydrous glucose to be given to the fasting patient and blood-glucose concentrations measured at intervals, to be given with 200-300 mL fluid.
**Oral glucose tolerance test for glucose**
- **Child** (By mouth): Test dose 1.75 g/kg (max. per dose 75 g), anhydrous glucose to be given to the fasting patient and blood-glucose concentrations measured at intervals. To be given with 200-300 mL fluid.
**Neonatal hypoglycaemia for glucose**
- **Neonate** (By intravenous infusion): 500 mg/kg/hour, to be administered as Glucose 10% intravenous infusion, an initial dose of 250 mg/kg over 5 minutes may be required if hypoglycaemia is severe enough to cause loss of consciousness or seizures.
**Hypoglycaemia for glucose**
- **Child up to 5 years** (By mouth): 5 g, repeated after 15 minutes if necessary, 5 g is 5 glucose tablets, or half a tube of glucose 40% oral gel. If oral glucose formulations are not available, the dose may be given using another fast-acting carbohydrate; 5 g is
- **Child 5-11 years** (By mouth): 10 g, repeated after 15 minutes if necessary, 10 g is If oral glucose formulations are not available, the dose may be given using another fast-acting carbohydrate; 10 g is
- **Child 12-17 years** (By mouth): 15 g, repeated after 15 minutes if necessary, 15 g is 5 tubes of glucose 40% oral gel. If oral glucose formulations are not available, the dose may be given using another fast-acting carbohydrate; 15 g is
- **Child** (By intravenous infusion): 500 mg/kg, to be administered as Glucose 10% intravenous infusion into a large vein through a large-gauge needle; care is required since this concentration is irritant.
**Hypoglycaemia [in conscious but uncooperative patients] for glucose**
- **Child up to 5 years** (By buccal administration): 5 g, repeated after 15 minutes if necessary, to be given as half a tube of glucose 40% oral gel.
- **Child 5-11 years** (By buccal administration): 10 g, repeated after 15 minutes if necessary, to be given as 1 tube of glucose 40% oral gel.
- **Child 12-17 years** (By buccal administration): 15 g, repeated after 15 minutes if necessary, to be given as 1.5 tubes of glucose 40% oral gel.
**Energy source for glucose**
- **Child** (By intravenous infusion): (consult product literature).
**Fluid and carbohydrate replacement for glucose**
- **Child** (By intravenous infusion): The volume of glucose solution needed to replace deficits may vary (consult product literature).
**Persistent cyanosis (in combination with propranolol) when blood glucose less than 3 mmol/litre (followed by morphine) for glucose**
- **Child** (By intravenous infusion): 200 mg/kg, to be administered as Glucose 10% intravenous infusion over 10 minutes.
**Diabetic ketoacidosis for glucose**
- **Child** (By intravenous infusion): (consult local protocol).
Cautions
Do not give alone except when there is no significant loss of electrolytes; prolonged administration of glucose solutions without electrolytes can lead to hyponatraemia and other electrolyte disturbances
Side effects
Frequency not known Chills; electrolyte imbalance; fever; fluid imbalance; hypersensitivity; local reaction; localised pain; polyuria; rash; venous thrombosis
Interactions
**Other interactions (2):**
- Drugs leading to an increased vasopressin effect.
- The below listed drugs increase the vasopressin effect, leading to reduced renal electrolyte free water excretion and increase the risk of hospital acquired hyponatraemia following inappropriately...
Medicinal forms
Solution,Solution,Gel,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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