Formulary
Glibenclamide: Indications, Dosing, Side Effects and Interactions
The sulfonylureas act mainly by augmenting insulin secretion and consequently are effective only when some residual pancreatic beta-cell activity is present;...
MedNext Academy | 3 min read
Glibenclamide: Indications, Dosing, Side Effects and Interactions
The sulfonylureas act mainly by augmenting insulin secretion and consequently are effective only when some residual pancreatic beta-cell activity is present;...
Drug action
The sulfonylureas act mainly by augmenting insulin secretion and consequently are effective only when some residual pancreatic beta-cell activity is present; during long-term administration they also have an extrapancreatic action.
Indications and dose
**Neonatal diabetes mellitus (initiated by a specialist) for glibenclamide**
- **Neonate** (By mouth using oral suspension): Initially 0.2 mg/kg daily in 2 divided doses, before feeding, increase dose according to product literature; usual maintenance 0.2-0.5 mg/kg daily in 2-4 divided doses, oral suspension is available in 2 different strengths and contains sodium benzoate-see Prescribing and dispensing information for information regarding the maximum volume per day.
- **Child** (By mouth using oral suspension): Initially 0.2 mg/kg daily in 2 divided doses, before feeding, increase dose according to product literature; usual maintenance 0.2-0.5 mg/kg daily in 2-4 divided doses, oral suspension is available in 2 different strengths and contains sodium benzoate-see Prescribing and dispensing information for information regarding the maximum volume per day.
Interactions
**Severe interactions:**
- Interaction studies with medicinal products also metabolized with these pathways, like carbamazepine, diazepam, glibenclamide, nifedipine, and an oral contraceptive containing levonorgestrel and...
- No clinically significant pharmacokinetic interaction was observed between sirolimus and any of the following substances: acyclovir, atorvastatin, digoxin, glibenclamide, methylprednisolone,...
**Other interactions (26):**
- Interaction studies conducted in healthy volunteers suggest that the pharmacokinetics of linagliptin were not influenced by co-administration with metformin and glibenclamide.
- Linagliptin had no clinically relevant effect on the pharmacokinetics of metformin, glibenclamide, simvastatin, pioglitazone, warfarin, digoxin, empagliflozin or oral contraceptives providing in...
- Sulphonylureas (Chlorpropamide, Glibenclamide, Glipizide, Tolbutamide): Fluconazole has been shown to prolong the serum half-life of concomitantly administered oral sulphonylureas (e.g.
- Others In drug interaction studies with valsartan, no interactions of clinical significance have been found with valsartan or any of the following substances: cimetidine, warfarin, furosemide,...
- Interactions to be considered The anticoagulant effect may be potentiated by concomitant administration of the following drugs: allopurinol; anabolic steroids; androgens; anti-arrhythmic...
- Sinthrome may potentiate the hypoglycaemic effect of sulphonylurea derivatives e.g.
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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