Formulary
Galsulfase: Indications, Dosing, Side Effects and Interactions
Galsulfase is a recombinant form of human N-acetylgalactosamine-4-sulfatase.
MedNext Academy | 3 min read
Galsulfase: Indications, Dosing, Side Effects and Interactions
Galsulfase is a recombinant form of human N-acetylgalactosamine-4-sulfatase.
Drug action
Galsulfase is a recombinant form of human N-acetylgalactosamine-4-sulfatase.
Indications and dose
**Mucopolysaccharidosis VI (specialist use only)**
- **Adult** (By Intravenous Infusion): 1 mg/kg once weekly.
**Mucopolysaccharidosis VI (specialist use only) for galsulfase**
- **Child 5-17 years** (By intravenous infusion): 1 mg/kg once weekly.
Cautions
Acute febrile illness (consider delaying treatment); acute respiratory illness (consider delaying treatment); infusion-related reactions can occur; respiratory disease
Side effects
Common or very common Abdominal pain; angioedema; apnoea; arthralgia; asthma; chest pain; chills; conjunctivitis; corneal opacity; cough; dyspnoea; ear pain; fever; headache; hearing impairment; hypertension; hypotension; increased risk of infection; malaise; nasal congestion; nausea; pain; reflexes absent; respiratory disorders; skin reactions; tremor; umbilical hernia; vomiting Frequency not known Arrhythmias; cyanosis; hypoxia; infusion related reaction; nerve disorders; pallor; paraesthesia; shock Side-effects, further information Infusion-related reactions often occur, they can be managed by slowing the infusion rate or interrupting the infusion, and can be minimised by pre-treatment with an antihistamine and an antipyretic. Recurrent infusion-related reactions may require pre-treatment with a corticosteroid - consult product literature for details.
Pregnancy
Manufacturer advises avoid unless essential.
Breast feeding
Manufacturer advises avoid-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Galsulfase in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

