Formulary
Fresh frozen plasma: Indications, Dosing, Side Effects and Interactions
Fresh frozen plasma clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Fresh frozen plasma: Indications, Dosing, Side Effects and Interactions
Fresh frozen plasma clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Replacement of coagulation factors or other plasma proteins (specialist use only)**
- **Adult** (By Intravenous Infusion): Specialist indication - access specialist resources for dosing information.
**Major bleeding in patients on warfarin [following phytomenadione if dried prothrombin complex is unavailable]**
- **Adult** (By Intravenous Infusion): 15 mL/kilogram.
Cautions
For fresh frozen plasma Cardiac decompensation; pulmonary oedema; risk of thrombosis; severe protein S deficiency (avoid products with low protein S activity e.g. OctaplasLG ); vaccination against hepatitis A and hepatitis B may be required
Contraindications
For fresh frozen plasma Avoid use as a volume expander; IgA deficiency with confirmed antibodies to IgA
Side effects
For fresh frozen plasma Common or very common Skin reactions Uncommon Fever; hypersensitivity; hypoxia; nausea; sensation abnormal; vomiting Rare or very rare Abdominal pain; anxiety; arrhythmias; back pain; cardiac arrest; chest discomfort; chills; circulatory collapse; citrate toxicity; dizziness; dyspnoea; flushing; haemolytic anaemia; haemorrhage; hyperhidrosis; hypertension; hypotension; localised oedema; malaise; procedural complications; pulmonary oedema; respiratory disorders; thromboembolism
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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