Formulary
Fluocinolone acetonide: Indications, Dosing, Side Effects and Interactions
Fluocinolone acetonide clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Fluocinolone acetonide: Indications, Dosing, Side Effects and Interactions
Fluocinolone acetonide clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Severe inflammatory skin disorders such as eczemas,Psoriasis**
- **Child** (To The Skin): 1-17 years Apply 1-2 times a day, to be applied thinly, reduce strength as condition responds.
- **Adult** (To The Skin): Apply 1-2 times a day, to be applied thinly, reduce strength as condition responds.
**Severe inflammatory skin disorders such as eczemas, Psoriasis for fluocinolone acetonide**
- **Child 1-17 years** (To the skin): Apply 1-2 times a day, to be applied thinly, reduce strength as condition responds.
Cautions
For all corticosteroids (topical) Avoid prolonged use (particularly on the face); cautions applicable to systemic corticosteroids may also apply if absorption occurs following topical and local use; dermatoses of infancy, including nappy rash (extreme caution required-treatment should be limited to 5-7 days) (in children); infection; keep away from eyes; use potent or very potent topical corticosteroids under specialist supervision (in children); use potent or very potent topical corticosteroids under specialist supervision in psoriasis (can result in rebound relapse, development of generalised pustular psoriasis, and local and systemic toxicity) (in adults) Cautions For fluocinolone acetonide With intravitreal use Raised baseline intra-ocular pressure (in adults)
Contraindications
For all corticosteroids (topical) Acne; perioral dermatitis; potent corticosteroids in widespread plaque psoriasis; rosacea; untreated bacterial, fungal or viral skin lesions Contra-indications For fluocinolone acetonide With intravitreal use Active or suspected ocular infection (in adults); active or suspected peri-ocular infection (in adults); pre-existing glaucoma (in adults)
Side effects
For all corticosteroids (topical) Common or very common Skin reactions; telangiectasia Rare or very rare Adrenal suppression; hypertrichosis; skin depigmentation (may be reversible) Frequency not known Local reaction; vasodilation Side-effects, further information Side-effects applicable to systemic corticosteroids may also apply if absorption occurs following topical and local use. In order to minimise the side-effects of a topical corticosteroid, it is important to apply it thinly to affected areas only, no more frequently than twice daily, and to use the least potent formulation which is fully effective. Side-effects For fluocinolone acetonide Common or very common With intravitreal use Cataract (in adults); dry eye (in adults); eye discomfort (in adults); eye disorders (in adults); glaucoma (in adults); haemorrhage (in adults); vision disorders (in adults) Uncommon With intravitreal use Corneal deposits (in adults); eye inflammation (in adults); headache (in adults); optic nerve disorder (in adults) Frequency not known With intravitreal use Thromboembolism (in adults)
Interactions
**Other interactions (2):**
- The systemic administration of some quinolones has been shown to enhance the effects of the oral anticoagulant, warfarin, and its derivatives, and has been associated with transient elevations in...
- Oral administration of ciprofloxacin has been shown to inhibit cytochrome P450 CYP1A2 and CYP3A4 isozymes, and alter the metabolism of methylxanthine compounds (caffeine, theophylline).
Pregnancy
With intravitreal use in adults: Manufacturer advises avoid unless potential benefit outweighs risk-no information available.
Breast feeding
With intravitreal use in adults: Manufacturer advises avoid unless essential.
Medicinal forms
Cream,Gel,Ointment
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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