Formulary
Fludarabine phosphate [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Fludarabine phosphate [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Fludarabine phosphate [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Fludarabine phosphate [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Chronic lymphocytic leukaemia**
- **Adult** (By Mouth, Or By Intravenous Injection, Or By Intravenous Infusion): Specialist drug - access specialist resources for dosing information.
Contraindications
For fludarabine phosphate [Specialist drug] Haemolytic anaemia
Side effects
For fludarabine phosphate [Specialist drug] General side-effects: Common or very common Anaemia; appetite decreased; asthenia; bone marrow depression (may be cumulative); chills; cough; diarrhoea; fever; increased risk of infection; malaise; mucositis; nausea; neoplasms; nerve disorders; neutropenia; oedema; stomatitis; thrombocytopenia; vision disorders; vomiting Uncommon Autoimmune disorder; confusion; dyspnoea; haemorrhage; pneumonitis; pulmonary fibrosis; pulmonary toxicity; tumour lysis syndrome Rare or very rare Agitation; arrhythmia; coma; heart failure; seizure; severe cutaneous adverse reactions (SCARs) Specific side-effects: Common or very common With oral use Progressive multifocal leukoencephalopathy (PML); skin reactions; viral infection reactivation With parenteral use Rash Uncommon With oral use Acquired haemophilia; crystalluria; electrolyte imbalance; haemolytic anaemia; hyperuricaemia; metabolic acidosis; renal failure Frequency not known With oral use Posterior reversible encephalopathy syndrome (PRES) With parenteral use Encephalopathy; intracranial haemorrhage
Medicinal forms
Tablet,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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