Formulary
Fexofenadine hydrochloride: Indications, Dosing, Side Effects and Interactions
Fexofenadine hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Fexofenadine hydrochloride: Indications, Dosing, Side Effects and Interactions
Fexofenadine hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Symptomatic relief of seasonal allergic rhinitis**
- **Child** (By Mouth): 12-17 years 120 mg once daily.
- **Adult** (By Mouth): 120 mg once daily.
**Symptomatic relief of chronic idiopathic urticaria**
- **Child** (By Mouth): 12-17 years 180 mg once daily.
- **Adult** (By Mouth): 180 mg once daily.
**Symptomatic relief of seasonal allergic rhinitis for fexofenadine hydrochloride**
- **Child 6-11 years** (By mouth): 30 mg twice daily.
- **Child 12-17 years** (By mouth): 120 mg once daily.
**Symptomatic relief of chronic idiopathic urticaria for fexofenadine hydrochloride**
- **Child 12-17 years** (By mouth): 180 mg once daily.
Side effects
Common or very common Dizziness; drowsiness; headache; nausea Uncommon Fatigue Frequency not known Diarrhoea; nervousness; palpitations; skin reactions; sleep disorders; tachycardia Side-effects, further information Non-sedating antihistamines such as fexofenadine cause less sedation and psychomotor impairment than the older antihistamines, but can still occur; sedation is generally minimal. This is because non-sedating antihistamines penetrate the blood brain barrier to a much lesser extent.
Interactions
**Other interactions (5):**
- Fexofenadine does not undergo hepatic biotransformation and therefore will not interact with other medicinal products through hepatic mechanisms.
- Fexofenadine is a P-glycoprotein (P-gp) and organic-anion-transporting polypeptide (OATP) substrate.
- Coadministration of fexofenadine hydrochloride with P-gp inhibitors, erythromycin or ketoconazole has been found to result in a 2-3 times increase in the level of fexofenadine in plasma.
- A clinical drug-drug interaction study showed that co-administration of apalutamide (a weak inducer of P-gp) and a single oral dose of 30 mg fexofenadine resulted in a 30 % decrease in AUC of...
- No interaction between fexofenadine and omeprazole was observed.
Pregnancy
Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity.
Breast feeding
Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.
Medicinal forms
Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
Inside MedNext for this topic
- 411 MedNext-authored chapters
- 80,000+ MCQ bank
- 15 study modes
- Growing visual cheat sheets
Study modes
- Notes
- MCQ
- Audio
- Video
- Visual
- 3D Anatomy
- Trace
- Flashcards
- Mnemonics
- Image Bank
- Clinical
- Microscopy
- Audio QBank
- Cadaver
- Book Match
Continue reading
Subject HubPharmacology Hub
All pharmacology resources in one place.
Drug SchedulesIndian Drug Schedules
Schedule H, H1, X and G classifications.
FormularyBrowse all drugs
Search 1,850+ drug profiles.
Study Fexofenadine hydrochloride in the MedNext app
Challenge yourself with targeted pharmacology MCQs on this drug class. Every explanation links back to the chapter that teaches the concept.
Start drug challengeExplore the full formulary

