Formulary
Fedratinib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Fedratinib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Fedratinib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Fedratinib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Disease-related splenomegaly or symptoms [in patients with primary myelofibrosis, post-polycythaemia vera myelofibrosis, or post-essential thrombocythaemia myelofibrosis]**
- **Adult** (By Mouth): Specialist drug - access specialist resources for dosing information.
Contraindications
For fedratinib [Specialist drug] Absolute neutrophil count less than 1x10 9 cells/litre (do not initiate); platelet count less than 50x10 9 /litre (do not initiate); thiamine deficiency
Side effects
For fedratinib [Specialist drug] Common or very common Anaemia; asthenia; constipation; diarrhoea; dizziness; dyspepsia; dysuria; haemorrhage; headache; hypertension; muscle spasms; nausea; neutropenia; pain; thrombocytopenia; urinary tract infection; vomiting; weight increased; Wernicke's encephalopathy Frequency not known Hepatic failure; pancreatitis Side-effects, further information Nausea is very common, often occurring within 2 days of starting treatment. Nausea can be managed by prescribing concurrent antiemetics (consult product literature), and/or taking doses with a high fat meal.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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