Formulary
Etoricoxib: Indications, Dosing, Side Effects and Interactions
Etoricoxib clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 4 min read
Etoricoxib: Indications, Dosing, Side Effects and Interactions
Etoricoxib clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Pain and inflammation in osteoarthritis**
- **Child** (By Mouth): 16-17 years 30 mg once daily, increased if necessary to 60 mg once daily.
- **Adult** (By Mouth): 30 mg once daily, increased if necessary to 60 mg once daily.
**Pain and inflammation in rheumatoid arthritis,Ankylosing spondylitis**
- **Child** (By Mouth): 16-17 years 60 mg once daily, increased if necessary to 90 mg once daily.
- **Adult** (By Mouth): 60 mg once daily, increased if necessary to 90 mg once daily.
**Acute gout**
- **Child** (By Mouth): 16-17 years 120 mg once daily for maximum 8 days.
- **Adult** (By Mouth): 120 mg once daily for maximum 8 days.
**Pain and inflammation in osteoarthritis for etoricoxib**
- **Child 16-17 years** (By mouth): 30 mg once daily, increased if necessary to 60 mg once daily.
**Pain and inflammation in rheumatoid arthritis, Ankylosing spondylitis for etoricoxib**
- **Child 16-17 years** (By mouth): 60 mg once daily, increased if necessary to 90 mg once daily.
**Acute gout for etoricoxib**
- **Child 16-17 years** (By mouth): 120 mg once daily for maximum 8 days.
Cautions
General cautions: Allergic disorders; cardiac impairment (NSAIDs may impair renal function); coagulation defects; connective-tissue disorders; dehydration (risk of renal impairment); history of cardiac failure; history of gastro-intestinal disorders; hypertension; left ventricular dysfunction; may mask symptoms of infection; oedema; risk factors for cardiovascular events Specific cautions: With systemic use Elderly (risk of serious side-effects and fatalities) (in adults)
Contraindications
Active gastro-intestinal bleeding; active gastro-intestinal ulceration; cerebrovascular disease; inflammatory bowel disease; ischaemic heart disease; mild to severe heart failure; peripheral arterial disease; uncontrolled hypertension (persistently above 140/90 mmHg)
Side effects
Common or very common Arrhythmias; asthenia; bronchospasm; constipation; diarrhoea; dizziness; fluid retention; gastrointestinal discomfort; gastrointestinal disorders; headache; hypertension; increased risk of infection; influenza like illness; nausea; oedema; oral ulceration; palpitations; skin reactions; vomiting Uncommon Alertness decreased; anaemia; angina pectoris; anxiety; appetite abnormal; cerebrovascular insufficiency; chest pain; congestive heart failure; conjunctivitis; cough; depression; drowsiness; dry mouth; dyspnoea; flushing; haemorrhage; hallucination; hyperkalaemia; hypersensitivity; insomnia; irritable bowel syndrome; leucopenia; myocardial infarction; pancreatitis; proteinuria; renal failure (more common in patients with pre-existing renal impairment); sensation abnormal; taste altered; thrombocytopenia; tinnitus; vasculitis; vertigo; vision blurred; weight increased Rare or very rare Angioedema; confusion; hepatic disorders; muscle complaints; severe cutaneous adverse reactions (SCARs); shock Frequency not known Nephritis tubulointerstitial; nephropathy Side-effects, further information For information about cardiovascular and gastrointestinal side-effects, and a possible exacerbation of symptoms in asthma, see Non-steroidal anti-inflammatory drugs
Interactions
**Other interactions (39):**
- Pharmacodynamic interactions Oral anticoagulants: In subjects stabilised on chronic warfarin therapy, the administration of etoricoxib 120 mg daily was associated with an approximate 13 % increase...
- Therefore, patients receiving oral anticoagulants should be closely monitored for their prothrombin time INR, particularly in the first few days when therapy with etoricoxib is initiated or the dose...
- Diuretics, ACE inhibitors and Angiotensin II Antagonists: NSAIDs may reduce the effect of diuretics and other antihypertensive drugs.
- These interactions should be considered in patients taking etoricoxib concomitantly with ACE inhibitors or angiotensin II antagonists.
- Acetylsalicylic Acid: In a study in healthy subjects, at steady state, etoricoxib 120 mg once daily had no effect on the anti-platelet activity of acetylsalicylic acid (81 mg once daily).
- Etoricoxib can be used concomitantly with acetylsalicylic acid at doses used for cardiovascular prophylaxis (low-dose acetylsalicylic acid).
Pregnancy
Manufacturer advises avoid (teratogenic in animal studies). Avoid during the third trimester (risk of closure of fetal ductus arteriosus in utero and possibly persistent pulmonary hypertension of the newborn); onset of labour may be delayed and duration may be increased.
Breast feeding
Use with caution during breast-feeding. Manufacturer advises avoid-present in milk in animal studies.
Hepatic impairment
Manufacturer advises caution in mild to moderate impairment; avoid in severe impairment (no information available). Dose adjustments Manufacturer advises max. 60 mg once daily in mild impairment; max. 30 mg once daily in moderate impairment.
Renal impairment
In general, for NSAIDs the MHRA advises to avoid where possible; if necessary, use with caution (risk of fluid retention and further renal impairment, including renal failure). For etoricoxib , avoid if creatinine clearance less than 30 mL/ minute. M See Prescribing in renal impairment .
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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