Formulary
Etelcalcetide: Indications, Dosing, Side Effects and Interactions
Etelcalcetide reduces parathyroid hormone secretion, which leads to a decrease in serum calcium concentrations.
MedNext Academy | 3 min read
Etelcalcetide: Indications, Dosing, Side Effects and Interactions
Etelcalcetide reduces parathyroid hormone secretion, which leads to a decrease in serum calcium concentrations.
Drug action
Etelcalcetide reduces parathyroid hormone secretion, which leads to a decrease in serum calcium concentrations.
Indications and dose
**Secondary hyperparathyroidism in patients with chronic kidney disease on haemodialysis**
- **Adult** (By Intravenous Injection): Initially 5 mg 3 times a week, then increased in steps of 2.5-5 mg if required, dose to be increased at intervals of at least 4 weeks; usual maintenance 2.5-15 mg 3 times a week, max. dose 15 mg 3 times a week; consult product literature for information on missed doses, and for dose adjustment due to parathyroid hormone levels or serum-calcium concentrations.
Cautions
Conditions that may worsen with hypocalcaemia; hypocalcaemia (do not initiate if serum-calcium concentration is less than the lower limit of normal range); switching from cinacalcet (do not initiate until 7 days after the last dose of cinacalcet) Cautions, further information Conditions that may worsen with hypocalcaemia Manufacturer advises caution with use in patients with conditions that may worsen with hypocalcaemia, including predisposition to QT-interval prolongation, history of seizures, and history of congestive heart failure-serum-calcium concentration should be closely monitored.
Side effects
Common or very common Diarrhoea; electrolyte imbalance; headache; heart failure aggravated; hypotension; muscle complaints; nausea; QT interval prolongation; sensation abnormal; vomiting Uncommon Seizure Frequency not known Anaphylactic reaction Side-effects, further information Manufacturer advises if formation of anti-etelcalcetide antibodies with a clinically significant effect is suspected, contact manufacturer to discuss antibody testing.
Pregnancy
Manufacturer advises avoid-limited information available.
Breast feeding
Manufacturer advises avoid-present in milk in animal studies.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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