Formulary
Estradiol with dydrogesterone: Indications, Dosing, Side Effects and Interactions
Estradiol with dydrogesterone clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Estradiol with dydrogesterone: Indications, Dosing, Side Effects and Interactions
Estradiol with dydrogesterone clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Menopausal symptoms in women with a uterus**
- **Adult** (By Mouth): 1 tablet daily for 14 days, red tablet to be taken and started within 5 days of onset of menstruation (or any time if cycles have ceased or are infrequent), then 1 tablet daily for 14 days, yellow tablet to be taken, subsequent courses repeated without interval, Femoston 1 mg/10 mg given initially and Femoston 2 mg/ 10 mg substituted if symptoms not controlled.
**Osteoporosis prophylaxis in women with a uterus**
- **Adult** (By Mouth): 1 tablet daily for 14 days, red tablet to be taken and started within 5 days of onset of menstruation (or any time if cycles have ceased or are infrequent), then 1 tablet daily for 14 days, yellow tablet to be taken, subsequent courses repeated without interval.
**Menopausal symptoms in women with a uterus whose last menstrual period occurred over 12 months previously**
- **Adult** (By Mouth): 1 tablet daily continuously, if changing from cyclical HRT begin treatment the day after finishing oestrogen plus progestogen phase.
**Menopausal symptoms in women with a uterus whose last menstrual period occurred over 12 months previously,Osteoporosis prophylaxis in women with a uterus whose last menstrual period occurred over 12 months previously**
- **Adult** (By Mouth): 1 tablet daily continuously, if changing from cyclical HRT begin treatment the day after finishing oestrogen plus progestogen phase.
Side effects
For estradiol with dydrogesterone Common or very common Asthenia; breast abnormalities; cervical abnormalities; depression; dizziness; flatulence; gastrointestinal discomfort; headaches; malaise; menstrual cycle irregularities; nausea; nervousness; pain; pelvic pain; peripheral oedema; postmenopausal haemorrhage; skin reactions; vomiting; vulvovaginal candidiasis; weight changes Uncommon Cystitis-like symptom; embolism and thrombosis; gallbladder disorder; hepatic function abnormal; hypertension; libido disorder; peripheral vascular disease; tumour growth; varicose veins Rare or very rare Angioedema; myocardial infarction Frequency not known Chorea; contact lens intolerance; dementia; epilepsy exacerbated; erythema nodosum; haemolytic anaemia; hypertriglyceridaemia; leg cramps; neoplasms; pancreatitis; steepening of corneal curvature; systemic lupus erythematosus (SLE); urinary incontinence
Hepatic impairment
For estradiol with dydrogesterone Manufacturer advises caution; avoid in acute or active disease.
Renal impairment
For estradiol with dydrogesterone Use with caution. M
Medicinal forms
Tablet
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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