Formulary
Erenumab: Indications, Dosing, Side Effects and Interactions
Erenumab is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor, inhibiting the function of CGRP, and thereby...
MedNext Academy | 3 min read
Erenumab: Indications, Dosing, Side Effects and Interactions
Erenumab is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor, inhibiting the function of CGRP, and thereby...
Drug action
Erenumab is a human monoclonal antibody that binds to the calcitonin gene-related peptide (CGRP) receptor, inhibiting the function of CGRP, and thereby preventing migraine attacks.
Indications and dose
**Prophylaxis of migraine (in patients who have at least 4 migraine days per month) (initiated by a specialist)**
- **Adult** (By Subcutaneous Injection): 70 mg every 4 weeks; increased if necessary to 140 mg every 4 weeks, consider discontinuing if no response after 3 months of treatment.
Side effects
Common or very common Angioedema; constipation; hypersensitivity; muscle spasms; oedema; skin reactions; swelling Frequency not known Alopecia; oral disorders
Interactions
**Other interactions (1):**
- No interaction with oral contraceptives (ethinyl estradiol/norgestimate) or sumatriptan was observed in studies with healthy volunteers.
Pregnancy
Manufacturer advises avoid-limited information available.
Breast feeding
Manufacturer advises avoid during first few days after birth-possible risk from transfer of antibodies to infant. After this time, use during breast-feeding only if clinically needed.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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