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Elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil: Indications, Dosing, Side Effects and Interactions
Elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil: Indications, Dosing, Side Effects and Interactions
Elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**HIV infection**
- **Adult** (By Mouth): 1 tablet once daily.
Side effects
For elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil Common or very common Appetite decreased; asthenia; constipation; diarrhoea; dizziness; electrolyte imbalance; flatulence; gastrointestinal discomfort; headache; hyperbilirubinaemia; hyperglycaemia; hypersensitivity; hypertriglyceridaemia; nausea; neutropenia; pain; rash pustular; skin reactions; sleep disorders; vomiting Uncommon Anaemia; angioedema; depression (in patients with history of depression or psychiatric illness); muscle weakness; myopathy; pancreatitis; proteinuria; renal failure; renal tubular disorders; suicidal ideation (in patients with history of depression or psychiatric illness) Rare or very rare Acute tubular necrosis; hepatic disorders; lactic acidosis; nephritis; nephrogenic diabetes insipidus; osteomalacia Frequency not known Autoimmune disorder; Grave's disease; inflammation; osteonecrosis; weight increased
Pregnancy
Important safety information For elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil MHRA/CHM advice: Elvitegravir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1 (April 2019) Pharmacokinetic data show mean exposure of elvitegravir boosted with cobicistat (available in combination in Genvoya and Stribild ) to be lower during the second and third trimesters of pregnancy than postpartum. Low elvitegravir exposure may be associated with an increased risk of treatment failure and an increased risk of HIV-1 transmission to the unborn child. For further information, see Pregnancy .
Hepatic impairment
For elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil Manufacturer advises caution (increased risk of hepatic side-effects); avoid in severe impairment (no information available).
Renal impairment
For elvitegravir with cobicistat, emtricitabine and tenofovir disoproxil If creatinine clearance less than 90 mL/minute, only initiate Stribild if other treatments cannot be used (avoid initiating Stribild if creatinine clearance less than 70 mL/minute). M If creatinine clearance less than 70 mL/minute, only continue Stribild if potential benefit outweighs risk (discontinue Stribild if creatinine clearance less than 50 mL/minute). M See Prescribing in renal impairment .
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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