Formulary
Elosulfase alfa: Indications, Dosing, Side Effects and Interactions
Elosulfase alfa is an enzyme produced by recombinant DNA technology that provides replacement therapy in conditions caused by...
MedNext Academy | 3 min read
Elosulfase alfa: Indications, Dosing, Side Effects and Interactions
Elosulfase alfa is an enzyme produced by recombinant DNA technology that provides replacement therapy in conditions caused by...
Drug action
Elosulfase alfa is an enzyme produced by recombinant DNA technology that provides replacement therapy in conditions caused by N-acetylgalactosamine-6-sulfatase (GALNS) deficiency.
Indications and dose
**Mucopolysaccharidosis IVA (specialist use only)**
- **Adult** (By Intravenous Infusion): 2 mg/kg once weekly.
**Mucopolysaccharidosis IVA (specialist use only) for elosulfase alfa**
- **Neonate** (By intravenous infusion): 2 mg/kg once weekly.
- **Child** (By intravenous infusion): 2 mg/kg once weekly.
Cautions
Elderly-no information available; infusion-related reactions Cautions, further information Infusion-related reactions Infusion-related reactions can occur; manufacturer advises these may be minimised by pre-treatment with an antihistamine and antipyretic, given 30-60 minutes before treatment. If reaction is severe, stop infusion and start appropriate treatment. Caution and close monitoring is advised during re-administration following a severe reaction.
Side effects
Common or very common Chills; diarrhoea; dizziness; dyspnoea; fever; gastrointestinal discomfort; headache; hypersensitivity; myalgia; nausea; oropharyngeal pain; vomiting Frequency not known Infusion related reaction
Pregnancy
Manufacturer advises avoid unless essential-limited information available.
Breast feeding
Manufacturer advises use only if potential benefit outweighs risk-present in milk in animal studies.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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