Formulary
Eletriptan: Indications, Dosing, Side Effects and Interactions
Eletriptan clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Eletriptan: Indications, Dosing, Side Effects and Interactions
Eletriptan clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Treatment of acute migraine**
- **Adult** (By Mouth): 40 mg, followed by 40 mg after 2 hours if required, dose to be taken only if migraine recurs (patient not responding to initial dose should not take second dose for same attack); increased if necessary to 80 mg, dose to be taken for subsequent attacks if 40 mg dose inadequate; maximum 80 mg per day.
Cautions
Conditions which predispose to coronary artery disease; elderly
Contraindications
Arrhythmias; coronary vasospasm; heart failure; ischaemic heart disease; peripheral vascular disease; previous cerebrovascular accident; previous myocardial infarction; previous transient ischaemic attack; Prinzmetal's angina; severe hypertension; uncontrolled hypertension
Side effects
Common or very common Arrhythmias; asthenia; chest discomfort; chills; dizziness; drowsiness; dry mouth; feeling hot; flushing; gastrointestinal discomfort; headache; hyperhidrosis; increased risk of infection; muscle complaints; muscle tone increased; muscle weakness; nausea; pain; palpitations; sensation abnormal; throat tightness; vertigo Uncommon Agitation; appetite decreased; arthralgia; arthritis; confusion; depersonalisation; depression; diarrhoea; dyspnoea; ear pain; eye pain; insomnia; lacrimation disorder; malaise; mood altered; movement disorders; oedema; oral disorders; peripheral vascular disease; respiratory disorder; skin reactions; speech disorder; stupor; taste altered; thinking abnormal; thirst; tinnitus; tremor; urinary disorders; urinary tract disorder; vision disorders; yawning Rare or very rare Asthma; breast pain; burping; conjunctivitis; constipation; gastrointestinal disorders; hyperbilirubinaemia; lymphadenopathy; menorrhagia; myopathy; shock; voice alteration Frequency not known Coronary vasospasm; hypertension; myocardial infarction; myocardial ischaemia; serotonin syndrome; stroke; syncope; vomiting Side-effects, further information Discontinue if symptoms of heat, heaviness, pressure or tightness (including throat and chest) occur.
Interactions
**Severe interactions:**
- Closely monitor when Duvyzat is used in combination with orally administered CYP3A4 sensitive substrates (e.g., alfentanil, tacrolimus, sirolimus, lovastatin, simvastatin, indinavir, sildenafil,...
**Other interactions (1):**
- Triptans Additive vasoconstriction may occur when ergometrine is concomitantly given with triptans (e.g.
Pregnancy
There is limited experience of using 5HT 1 -receptor agonists during pregnancy; manufacturers advise that they should be avoided unless the potential benefit outweighs the risk.
Breast feeding
Present in milk-avoid breast-feeding for 24 hours.
Hepatic impairment
Manufacturer advises avoid in severe impairment.
Renal impairment
Avoid if creatinine clearance less than 30 mL/minute, M see Prescribing in renal impairment . Dose adjustments Reduce initial dose to 20 mg (maximum 40 mg in 24 hours) in mild to moderate impairment. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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