Formulary
Elafibranor: Indications, Dosing, Side Effects and Interactions
Elafibranor is a peroxisome proliferator-activated receptor (PPAR) alpha and delta agonist that decreases bile acid synthesis and exerts an anti-inflammatory...
MedNext Academy | 3 min read
Elafibranor: Indications, Dosing, Side Effects and Interactions
Elafibranor is a peroxisome proliferator-activated receptor (PPAR) alpha and delta agonist that decreases bile acid synthesis and exerts an anti-inflammatory...
Drug action
Elafibranor is a peroxisome proliferator-activated receptor (PPAR) alpha and delta agonist that decreases bile acid synthesis and exerts an anti-inflammatory effect, reducing inflammation and scarring in the liver.
Indications and dose
**Primary biliary cholangitis [in combination with ursodeoxycholic acid when response to ursodeoxycholic acid has been inadequate, or as monotherapy in patients intolerant of ursodeoxycholic acid]**
- **Adult** (By Mouth): 80 mg once daily.
Cautions
Risk factors for elevated creatine kinase concentration
Side effects
Common or very common Cholelithiasis; constipation; diarrhoea; gastrointestinal discomfort; headache; myalgia; nausea; vomiting Uncommon Pruritic rash Frequency not known Bone fracture
Interactions
**Other interactions (1):**
- Based on in vitro and in vivo studies, no clinically relevant drug-drug interaction is expected by co-administering elafibranor with any other medicinal products (see section 5.2).
Pregnancy
Avoid (toxicity in animal studies). M
Breast feeding
Avoid during treatment and for at least 3 weeks after last treatment (toxicity in animal studies). M
Hepatic impairment
Avoid in severe impairment (risk of increased exposure). M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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