Formulary
Diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine: Indications, Dosing, Side Effects and Interactions
For diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine Diphtheria with tetanus, pertussis, poliomyelitis and...
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Diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine: Indications, Dosing, Side Effects and Interactions
For diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine Diphtheria with tetanus, pertussis, poliomyelitis and...
Drug action
For diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine Diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine is a non-live combination vaccine.
Indications and dose
**Primary immunisation**
- **Child** (By Intramuscular Injection): 2 months-9 years 0.5 mL every month for 3 doses.
**Primary immunisation for diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine**
- **Child 2 months-9 years** (By intramuscular injection): 0.5 mL every month for 3 doses.
Cautions
For all vaccines, general Acute illness; minor illnesses Cautions, further information Illness UKHSA advises vaccination may be postponed if the individual is suffering from an acute illness; however, it is not necessary to postpone immunisation in patients with minor illnesses without fever or systemic upset. Predisposition to neurological problems UKHSA advises: when there is a personal or family history of febrile convulsions, there is an increased risk of these occurring during fever from any cause including immunisation, but this is not a contra-indication to immunisation. In children who have had a seizure associated with fever without neurological deterioration, immunisation is recommended ; advice on the management of fever should be given before immunisation. When a child has had a convulsion not associated with fever, and the neurological condition is not deteriorating, immunisation is recommended ; children with stable neurological disorders (e.g. spina bifida, congenital brain abnormality, and peri-natal hypoxic-ischaemic encephalopathy) should be immunised according to the recommended schedule; when there is a still evolving neurological problem , including poorly controlled epilepsy, immunisation should be deferred and the child referred to a specialist. Immunisation is recommended if a cause for the neurological disorder is identified. If a cause is not identified, immunisation should be deferred until the condition is stable. Impaired immune response and drugs affecting immune response Immune response to vaccines may be reduced in immunosuppressed patients, UKHSA advises consider seeking specialist advice.
Side effects
For all vaccines, general Common or very common Abdominal pain; appetite decreased; arthralgia; diarrhoea; dizziness; fatigue; fever; headache; lymphadenopathy; malaise; myalgia; nausea; skin reactions; vomiting Uncommon Hypersensitivity Side-effects For diphtheria with tetanus, pertussis, poliomyelitis and haemophilus influenzae type b vaccine Common or very common Crying abnormal; drowsiness; irritability; restlessness Uncommon Cough; extensive swelling of vaccinated limb; increased risk of infection; rhinorrhoea Frequency not known Angioedema; apnoea; hypotonic-hyporesponsiveness episode; seizure Side-effects, further information The incidence of local and systemic reactions is lower with acellular pertussis vaccines than with whole-cell pertussis vaccines used previously. Compared with primary vaccination, injection site reactions are more common with booster doses of vaccines containing acellular pertussis. has advised (2016) that the vaccine should not be withheld from children with a history to a preceding dose of: fever, irrespective of severity; hypotonic-hyporesonsive episodes; persistent crying or screaming for more than 3 hours; severe local reaction, irrespective of extent.
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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