Formulary
Diphtheria with tetanus and poliomyelitis vaccine: Indications, Dosing, Side Effects and Interactions
For diphtheria with tetanus and poliomyelitis vaccine Diphtheria with tetanus and poliomyelitis vaccine is a non-live, adsorbed, combination vaccine...
MedNext Academy | 3 min read
Diphtheria with tetanus and poliomyelitis vaccine: Indications, Dosing, Side Effects and Interactions
For diphtheria with tetanus and poliomyelitis vaccine Diphtheria with tetanus and poliomyelitis vaccine is a non-live, adsorbed, combination vaccine...
Drug action
For diphtheria with tetanus and poliomyelitis vaccine Diphtheria with tetanus and poliomyelitis vaccine is a non-live, adsorbed, combination vaccine containing diphtheria and tetanus toxoids, and inactivated poliomyelitis virus.
Indications and dose
**Primary immunisation**
- **Child** (By Intramuscular Injection): 10-17 years 0.5 mL every month for 3 doses.
- **Adult** (By Intramuscular Injection): 0.5 mL every month for 3 doses.
**Booster doses**
- **Child** (By Intramuscular Injection): 10-17 years 0.5 mL for 1 dose, first booster dose-should be given at least 5 years after primary course, then 0.5 mL for 1 dose, second booster dose-should be given 10 years after first booster dose (this interval can be reduced to a minimum of 5 years if previous doses were delayed).
- **Adult** (By Intramuscular Injection): 0.5 mL for 1 dose, first booster dose-should be given at least 5 years after primary course, then 0.5 mL for 1 dose, second booster dose-should be given 10 years after first booster dose (this interval can be reduced to a minimum of 5 years if previous doses were delayed).
**Primary immunisation for diphtheria with tetanus and poliomyelitis vaccine**
- **Child 10-17 years** (By intramuscular injection): 0.5 mL every month for 3 doses.
**Booster doses for diphtheria with tetanus and poliomyelitis vaccine**
- **Child 10-17 years** (By intramuscular injection): 0.5 mL for 1 dose, first booster dose-should be given at least 5 years after primary course, then 0.5 mL for 1 dose, second booster dose-should be given 10 years after first booster dose (this interval can be reduced to a minimum of 5 years if previous doses were delayed).
Cautions
For all vaccines, general Acute illness; minor illnesses Cautions, further information Illness UKHSA advises vaccination may be postponed if the individual is suffering from an acute illness; however, it is not necessary to postpone immunisation in patients with minor illnesses without fever or systemic upset. Predisposition to neurological problems UKHSA advises: when there is a personal or family history of febrile convulsions, there is an increased risk of these occurring during fever from any cause including immunisation, but this is not a contra-indication to immunisation. In children who have had a seizure associated with fever without neurological deterioration, immunisation is recommended ; advice on the management of fever should be given before immunisation. When a child has had a convulsion not associated with fever, and the neurological condition is not deteriorating, immunisation is recommended ; children with stable neurological disorders (e.g. spina bifida, congenital brain abnormality, and peri-natal hypoxic-ischaemic encephalopathy) should be immunised according to the recommended schedule; when there is a still evolving neurological problem , including poorly controlled epilepsy, immunisation should be deferred and the child referred to a specialist. Immunisation is recommended if a cause for the neurological disorder is identified. If a cause is not identified, immunisation should be deferred until the condition is stable. Impaired immune response and drugs affecting immune response Immune response to vaccines may be reduced in immunosuppressed patients, UKHSA advises consider seeking specialist advice.
Side effects
For all vaccines, general Common or very common Abdominal pain; appetite decreased; arthralgia; diarrhoea; dizziness; fatigue; fever; headache; lymphadenopathy; malaise; myalgia; nausea; skin reactions; vomiting Uncommon Hypersensitivity Side-effects For diphtheria with tetanus and poliomyelitis vaccine Common or very common Vertigo Frequency not known Asthenia; chills; face oedema; influenza like illness; nerve disorders; pallor; seizure; shock; syncope; vaccination reactions
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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