Formulary
Diphtheria with tetanus and pertussis vaccine: Indications, Dosing, Side Effects and Interactions
For diphtheria with tetanus and pertussis vaccine Diphtheria with tetanus and pertussis vaccine is a non-live, adsorbed, combination vaccine containing...
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Diphtheria with tetanus and pertussis vaccine: Indications, Dosing, Side Effects and Interactions
For diphtheria with tetanus and pertussis vaccine Diphtheria with tetanus and pertussis vaccine is a non-live, adsorbed, combination vaccine containing...
Drug action
For diphtheria with tetanus and pertussis vaccine Diphtheria with tetanus and pertussis vaccine is a non-live, adsorbed, combination vaccine containing diphtheria and tetanus toxoids, and pertussis antigens.
Indications and dose
**Passive immunisation against pertussis [pregnant women in their second or third trimester] for diphtheria with tetanus and pertussis vaccine**
- **Females of childbearing potential** (By intramuscular injection): 0.5 mL for 1 dose.
Cautions
For all vaccines, general Acute illness; minor illnesses Cautions, further information Illness UKHSA advises vaccination may be postponed if the individual is suffering from an acute illness; however, it is not necessary to postpone immunisation in patients with minor illnesses without fever or systemic upset. Predisposition to neurological problems UKHSA advises: when there is a personal or family history of febrile convulsions, there is an increased risk of these occurring during fever from any cause including immunisation, but this is not a contra-indication to immunisation. In children who have had a seizure associated with fever without neurological deterioration, immunisation is recommended ; advice on the management of fever should be given before immunisation. When a child has had a convulsion not associated with fever, and the neurological condition is not deteriorating, immunisation is recommended ; children with stable neurological disorders (e.g. spina bifida, congenital brain abnormality, and peri-natal hypoxic-ischaemic encephalopathy) should be immunised according to the recommended schedule; when there is a still evolving neurological problem , including poorly controlled epilepsy, immunisation should be deferred and the child referred to a specialist. Immunisation is recommended if a cause for the neurological disorder is identified. If a cause is not identified, immunisation should be deferred until the condition is stable. Impaired immune response and drugs affecting immune response Immune response to vaccines may be reduced in immunosuppressed patients, UKHSA advises consider seeking specialist advice. Cautions For diphtheria with tetanus and pertussis vaccine Guillain-Barre syndrome within 6 weeks of previous immunisation with a vaccine containing tetanus toxoid; progressive neurological disorders, uncontrolled epilepsy, or progressive encephalopathy (defer immunisation until condition has stabilised)
Contraindications
For diphtheria with tetanus and pertussis vaccine History of encephalopathy of unknown origin within 7 days of previous immunisation with a pertussis-containing vaccine
Side effects
For all vaccines, general Common or very common Abdominal pain; appetite decreased; arthralgia; diarrhoea; dizziness; fatigue; fever; headache; lymphadenopathy; malaise; myalgia; nausea; skin reactions; vomiting Uncommon Hypersensitivity Side-effects For diphtheria with tetanus and pertussis vaccine Common or very common Asthenia; axillary lymphadenopathy; chills; generalised pain; joint swelling; muscle weakness Frequency not known Extensive swelling of vaccinated limb; facial paralysis; myelitis; myocarditis; myositis; nerve disorders; seizure; sensation abnormal; syncope
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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