Formulary
Dinoprostone: Indications, Dosing, Side Effects and Interactions
Dinoprostone clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Dinoprostone: Indications, Dosing, Side Effects and Interactions
Dinoprostone clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Maintaining patency of the ductus arteriosus for dinoprostone**
- **Neonate** (By continuous intravenous infusion): Initially 5 nanograms/kg/minute, then increased in steps of 5 nanograms/kg/minute as required; increased to 20 nanograms/kg/minute, doses up to 100 nanogram/kg/minute have been used but are associated with increased side-effects.
- **Neonate** (By mouth): 20-25 micrograms/kg every 1-2 hours, then increased if necessary to 40-50 micrograms/kg every 1-2 hours, if treatment continues for more than 1 week gradually reduce the dose.
Cautions
Effect of oxytocin enhanced; history of asthma; history of epilepsy; history of glaucoma and raised intra-ocular pressure; hypertension; risk factors for disseminated intravascular coagulation; uterine rupture; uterine scarring
Contraindications
Active cardiac disease; active pulmonary disease; avoid extra-amniotic route in cervicitis or vaginitis; fetal distress; fetal malpresentation; grand multiparas; history of caesarean section; history of difficult or traumatic delivery; history of major uterine surgery; major cephalopelvic disproportion; multiple pregnancy; placenta praevia or unexplained vaginal bleeding during pregnancy; ruptured membranes; untreated pelvic infection
Side effects
With vaginal use Amniotic cavity infection; febrile disorders; headache; hyperbilirubinaemia neonatal; hypotension; pruritus; uterine atony; vaginal burning Frequency not known With vaginal use Abdominal pain; diarrhoea; disseminated intravascular coagulation; genital oedema; nausea; uterine rupture; vomiting
Hepatic impairment
Manufacturer advises avoid.
Renal impairment
Avoid. M
Medicinal forms
Pessary,Gel
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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