Formulary
Desloratadine: Indications, Dosing, Side Effects and Interactions
Desloratadine clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Desloratadine: Indications, Dosing, Side Effects and Interactions
Desloratadine clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Symptomatic relief of allergy such as allergic rhinitis, urticaria, chronic idiopathic urticaria**
- **Child** (By Mouth): 12-17 years 5 mg once daily.
- **Adult** (By Mouth): 5 mg once daily.
**Symptomatic relief of allergy such as allergic rhinitis, urticaria, chronic idiopathic urticaria for desloratadine**
- **Child 1-5 years** (By mouth): 1.25 mg once daily.
- **Child 6-11 years** (By mouth): 2.5 mg once daily.
- **Child 12-17 years** (By mouth): 5 mg once daily.
Side effects
Common or very common Asthenia; dry mouth; headache Rare or very rare Akathisia; arrhythmias; diarrhoea; dizziness; drowsiness; gastrointestinal discomfort; hallucination; hepatic disorders; insomnia; myalgia; nausea; palpitations; seizure; vomiting Frequency not known Behaviour abnormal; photosensitivity reaction; QT interval prolongation Side-effects, further information Non-sedating antihistamines such as desloratadine cause less sedation and psychomotor impairment than the older antihistamines, but can still occur; sedation is generally minimal. This is because non-sedating antihistamines penetrate the blood brain barrier to a much lesser extent.
Interactions
**Other interactions (4):**
- No clinically relevant interactions were observed in clinical trials with desloratadine tablets in which erythromycin or ketoconazole were co-administered (see section 5.1).
- In a clinical pharmacology trial, desloratadine tablets taken concomitantly with alcohol did not potentiate the performance impairing effects of alcohol (see section 5.1).
- However, cases of alcohol intolerance and intoxication have been reported during postmarketing use.
- Therefore, caution is recommended if alcohol is taken concomitantly.
Pregnancy
Most manufacturers of antihistamines advise avoiding their use during pregnancy; however, there is no evidence of teratogenicity.
Breast feeding
Most antihistamines are present in breast milk in varying amounts; although not known to be harmful, most manufacturers advise avoiding their use in mothers who are breast-feeding.
Renal impairment
Use with caution in severe impairment. M
Medicinal forms
Tablet,Solution
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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