Formulary
Delgocitinib: Indications, Dosing, Side Effects and Interactions
Delgocitinib is a pan Janus-associated tyrosine kinase inhibitor of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2).
MedNext Academy | 3 min read
Delgocitinib: Indications, Dosing, Side Effects and Interactions
Delgocitinib is a pan Janus-associated tyrosine kinase inhibitor of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2).
Drug action
Delgocitinib is a pan Janus-associated tyrosine kinase inhibitor of JAK1, JAK2, JAK3, and tyrosine kinase 2 (TYK2).
Indications and dose
**Moderate-to-severe chronic hand eczema (under expert supervision)**
- **Adult** (To The Skin): Apply twice daily until symptoms resolve, to be applied thinly to affected areas on the hands and wrists approx. every 12 hours, discontinue if no response after 12 weeks, treatment may be re-initiated if flares occur.
Cautions
Avoid contact with eyes; avoid contact with mouth; avoid contact with mucous membranes
Side effects
Frequency not known Skin eruption localised
Interactions
**Other interactions (2):**
- No clinical interaction studies have been performed with topically or systemically administered delgocitinib (see section 5.2 for in vitro interaction studies).
- Delgocitinib has not been evaluated in combination with other topical medicinal products and co-application on the same skin area is not recommended.
Pregnancy
Avoid (limited information available). M
Breast feeding
Suitable for use in breast-feeding (negligible systemic exposure); avoid direct contact with breast or nipple area and infant's skin after application. M
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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