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Darunavir with cobicistat: Indications, Dosing, Side Effects and Interactions
Darunavir with cobicistat clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Darunavir with cobicistat: Indications, Dosing, Side Effects and Interactions
Darunavir with cobicistat clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**HIV infection, in combination with other antiretroviral drugs (initiated by a specialist)**
- **Adult** (By Mouth): 800/150 mg once daily.
**HIV infection, in combination with other antiretroviral drugs (initiated by a specialist) for darunavir with cobicistat**
- **Child 12-17 years (body-weight 40 kg and above)** (By mouth): 800/150 mg once daily.
Cautions
For darunavir with cobicistat Elderly
Contraindications
For darunavir with cobicistat Treatment-experienced patients with 1 or more darunavir resistance-associated mutations, plasma HIV-RNA concentration of 100 000 copies/mL or greater, or CD4 count less than 100 cells 10 6 /litre
Pregnancy
Important safety information For darunavir with cobicistat MHRA/CHM advice: Darunavir boosted with cobicistat: avoid use in pregnancy due to risk of treatment failure and maternal-to-child transmission of HIV-1 (July 2018) Pharmacokinetic data show mean exposure of darunavir boosted with cobicistat (available in combination in Rezolsta and Symtuza ) to be lower during the second and third trimesters of pregnancy than during 6-12 weeks postpartum. Low darunavir exposure may be associated with an increased risk of treatment failure and an increased risk of HIV-1 transmission to the unborn child. For further information, see Pregnancy .
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Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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