Formulary
Crizotinib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Crizotinib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Crizotinib [Specialist drug]: Indications, Dosing, Side Effects and Interactions
Crizotinib [Specialist drug] clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Non-small cell lung cancer**
- **Adult** (By Mouth): Specialist drug - access specialist resources for dosing information.
Side effects
For crizotinib [Specialist drug] Common or very common Acute respiratory distress syndrome (ARDS); anaemia; appetite decreased; arrhythmias; constipation; diarrhoea; dizziness; fatigue; gait abnormal; gastrointestinal discomfort; gastrointestinal disorders; gonadal hypofunction; heart failure; hepatic disorders; hypophosphataemia; interstitial lung disease; leucopenia; local swelling; movement disorders; muscle atrophy; muscle tone decreased; muscle weakness; nausea; nerve disorders; neuralgia; neurotoxicity; neutropenia; oedema; periorbital oedema; peroneal nerve palsy; pulmonary oedema; QT interval prolongation; renal abscess; renal disorders; sensation abnormal; skin reactions; syncope; taste altered; vision disorders; vitreous floater; vomiting Uncommon Gastrointestinal perforation (including fatal cases, discontinue); hepatic failure (including fatal cases); photosensitivity reaction; renal impairment Side-effects, further information Heart failure Consider reducing the dose, or interrupting or stopping treatment, if symptoms of heart failure occur. Interstitial lung disease Interstitial lung disease and pneumonitis, including fatal events, have been reported; withdraw treatment if suspected, and permanently discontinue treatment if diagnosed.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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