Formulary
Conestat alfa: Indications, Dosing, Side Effects and Interactions
Conestat alfa clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Conestat alfa: Indications, Dosing, Side Effects and Interactions
Conestat alfa clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Acute attacks of hereditary angioedema in patients with C1-esterase inhibitor deficiency (under expert supervision)**
- **Adult** (By Slow Intravenous Injection): (body-weight 84 kg and above) 4200 units for 1 dose, to be administered over 5 minutes, dose may be repeated if there has been an inadequate response after 120 minutes; maximum 2 doses per day.
**Acute attacks of hereditary angioedema in patients with C1-esterase inhibitor deficiency (under expert supervision) for conestat alfa**
- **Child 2-11 years (body-weight up to 84 kg)** (By slow intravenous injection): 50 units/kg for 1 dose, to be administered over 5 minutes, dose may be repeated if there has been an inadequate response after 60 minutes; maximum 2 doses per day.
- **Child 2-11 years (body-weight 84 kg and above)** (By slow intravenous injection): 4200 units for 1 dose, to be administered over 5 minutes, dose may be repeated if there has been an inadequate response after 60 minutes; maximum 2 doses per day.
- **Child 12-17 years (body-weight up to 84 kg)** (By slow intravenous injection): 50 units/kg for 1 dose, to be administered over 5 minutes, dose may be repeated if there has been an inadequate response after 120 minutes; maximum 2 doses per day.
- **Child 12-17 years (body-weight 84 kg and above)** (By slow intravenous injection): 4200 units for 1 dose, to be administered over 5 minutes, dose may be repeated if there has been an inadequate response after 120 minutes; maximum 2 doses per day.
Contraindications
Rabbit allergy
Side effects
Common or very common Nausea Uncommon Abdominal discomfort; auricular swelling; diarrhoea; dizziness; headache; numbness; oral paraesthesia; throat irritation; urticaria; vertigo
Pregnancy
Use only if potential benefit outweighs risk-toxicity in animal studies.
Breast feeding
Use only if potential benefit outweighs risk-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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