Formulary
Co-fluampicil: Indications, Dosing, Side Effects and Interactions
The penicillins are bactericidal and act by interfering with bacterial cell wall synthesis.
MedNext Academy | 3 min read
Co-fluampicil: Indications, Dosing, Side Effects and Interactions
The penicillins are bactericidal and act by interfering with bacterial cell wall synthesis.
Drug action
The penicillins are bactericidal and act by interfering with bacterial cell wall synthesis. They diffuse well into body tissues and fluids, but penetration into the cerebrospinal fluid is poor except when the meninges are inflamed. They are excreted in the urine in therapeutic concentrations.
Indications and dose
**Mixed infections involving beta-lactamase-producing staphylococci**
- **Child** (By Mouth): 10-17 years 250/250 mg every 6 hours.
- **Adult** (By Mouth): 250/250 mg every 6 hours.
**Severe mixed infections involving beta-lactamase-producing staphylococci**
- **Child** (By Mouth): 10-17 years 500/500 mg every 6 hours.
- **Adult** (By Mouth): 500/500 mg every 6 hours.
**Mixed infections involving beta-lactamase-producing staphylococci for co-fluampicil**
- **Child 10-17 years** (By mouth): 250/250 mg every 6 hours.
**Severe mixed infections involving beta-lactamase-producing staphylococci for co-fluampicil**
- **Child 10-17 years** (By mouth): 500/500 mg every 6 hours.
Cautions
History of allergy Cautions For co-fluampicil Acute lymphocytic leukaemia (increased risk of erythematous rashes); chronic lymphocytic leukaemia (increased risk of erythematous rashes); cytomegalovirus infection (increased risk of erythematous rashes); glandular fever (erythematous rashes common)
Side effects
Common or very common Diarrhoea; hypersensitivity; nausea; skin reactions; thrombocytopenia; vomiting Uncommon Arthralgia; leucopenia Rare or very rare Agranulocytosis; angioedema; haemolytic anaemia; hepatic disorders; nephritis tubulointerstitial; neutropenia; pseudomembranous enterocolitis; seizure; severe cutaneous adverse reactions (SCARs) Side-effects, further information Diarrhoea frequently occurs during oral penicillin therapy. It is most common with broad-spectrum penicillins, which can cause antibiotic-associated colitis. Side-effects For co-fluampicil Frequency not known Bronchospasm; coma; dyspnoea; electrolyte imbalance; eosinophilia; erythema nodosum; gastrointestinal disorder; hallucination; Jarisch-Herxheimer reaction; myalgia; purpura non-thrombocytopenic; vasculitis
Pregnancy
For co-fluampicil Not known to be harmful.
Breast feeding
For co-fluampicil Trace amount in milk, but appropriate to use.
Hepatic impairment
For co-fluampicil Manufacturer advises caution.
Renal impairment
For co-fluampicil Dose adjustments Reduce dose or frequency if creatinine clearance less than 10 mL/minute, M see Prescribing in renal impairment .
Medicinal forms
Medicinal forms No licensed medicines listed.
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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