Formulary
Clonazepam: Indications, Dosing, Side Effects and Interactions
Clonazepam clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Clonazepam: Indications, Dosing, Side Effects and Interactions
Clonazepam clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**All forms of epilepsy for clonazepam**
- **Child 1-11 months** (By mouth): Initially 250 micrograms once daily for 4 nights, dose to be increased over 2-4 weeks, usual dose 0.5-1 mg daily, dose to be taken at night; may be given in 3 divided doses if necessary.
- **Child 1-4 years** (By mouth): Initially 250 micrograms once daily for 4 nights, dose to be increased over 2-4 weeks, usual dose 1-3 mg daily, dose to be taken at night; may be given in 3 divided doses if necessary.
- **Child 5-11 years** (By mouth): Initially 500 micrograms once daily for 4 nights, dose to be increased over 2-4 weeks, usual dose 3-6 mg daily, dose to be taken at night; may be given in 3 divided doses if necessary.
- **Child 12-17 years** (By mouth): Initially 1 mg once daily for 4 nights, dose to be increased over 2-4 weeks, usual dose 4-8 mg daily, dose usually taken at night; may be given in 3-4 divided doses if necessary.
Interactions
**Other interactions (9):**
- Groups of medicinal products that can be affected include, but are not limited to: Analgesics (e.g.
- Co-administration of boosted darunavir with clonazepam may increase concentrations of clonazepam.
- Agents that may decrease carbamazepine plasma levels The dose of carbamazepine may have to be adjusted when used concomitantly with the substances described below: Antiepileptics: oxcarbazepine,...
- Antiemetics: aprepitant Antiepileptics: clobazam, clonazepam, ethosuximide, lamotrigine, eslicarbazepine, oxcarbazepine, primidone, tiagabine, topiramate, valproic acid, zonisamide.
- Interactions which may not be associated with increased or reduced lithium levels: Concomitant use of the following drugs may precipitate symptoms of toxicity when the lithium level is within the...
- AED coadministered Influence of AED on Perampanel Eisai concentration Influence of Perampanel Eisai on AED concentration Carbamazepine 3 fold decrease <10% decrease Clobazam No influence <10%...
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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