Formulary
Clofazimine: Indications, Dosing, Side Effects and Interactions
Clofazimine clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Clofazimine: Indications, Dosing, Side Effects and Interactions
Clofazimine clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Multibacillary leprosy in combination with rifampicin and dapsone (3-drug regimen) (administered on expert advice)**
- **Adult** (By Mouth): 300 mg once a month, to be administered under supervision and 50 mg daily, to be self-administered, alternatively 300 mg once a month, to be administered under supervision and 100 mg once daily on alternate days, to be self-administered.
**Lepromatous lepra reactions (administered on expert advice)**
- **Adult** (By Mouth): 300 mg daily for max. 3 months.
**Severe type II (erythema nodosum leprosum) reactions (administered on expert advice)**
- **Adult** (By Mouth): 100 mg 3 times a day for one month, subsequent dose reductions are required, may take 4-6 weeks to attain full effect.
Cautions
Avoid if persistent abdominal pain and diarrhoea; may discolour soft contact lenses
Side effects
Frequency not known Abdominal pain; appetite decreased; dry eye; eye discolouration; fatigue; gastrointestinal disorders; hair colour changes (reversible); headache; lymphadenopathy; nausea; photosensitivity reaction; red discolouration of body fluids; skin discolouration (including areas exposed to light); skin reactions; splenic infarction; urine discolouration; visual impairment; vomiting (hospitalise if persistent); weight decreased
Pregnancy
Use with caution.
Breast feeding
May alter colour of milk; skin discoloration of infant.
Hepatic impairment
Use with caution.
Renal impairment
Use with caution in severe impairment. M
Medicinal forms
Capsule
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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