Formulary
Clobetasone butyrate: Indications, Dosing, Side Effects and Interactions
Clobetasone butyrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Clobetasone butyrate: Indications, Dosing, Side Effects and Interactions
Clobetasone butyrate clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Eczemas and dermatitis of all types,Maintenance between courses of more potent corticosteroids**
- **Child** (To The Skin): Apply 1-2 times a day, to be applied thinly.
- **Adult** (To The Skin): Apply 1-2 times a day, to be applied thinly.
**Eczemas and dermatitis of all types, Maintenance between courses of more potent corticosteroids for clobetasone butyrate**
- **Child** (To the skin): Apply 1-2 times a day, to be applied thinly.
Cautions
For all corticosteroids (topical) Avoid prolonged use (particularly on the face); cautions applicable to systemic corticosteroids may also apply if absorption occurs following topical and local use; dermatoses of infancy, including nappy rash (extreme caution required-treatment should be limited to 5-7 days) (in children); infection; keep away from eyes; use potent or very potent topical corticosteroids under specialist supervision (in children); use potent or very potent topical corticosteroids under specialist supervision in psoriasis (can result in rebound relapse, development of generalised pustular psoriasis, and local and systemic toxicity) (in adults)
Contraindications
For all corticosteroids (topical) Acne; perioral dermatitis; potent corticosteroids in widespread plaque psoriasis; rosacea; untreated bacterial, fungal or viral skin lesions
Side effects
For all corticosteroids (topical) Common or very common Skin reactions; telangiectasia Rare or very rare Adrenal suppression; hypertrichosis; skin depigmentation (may be reversible) Frequency not known Local reaction; vasodilation Side-effects, further information Side-effects applicable to systemic corticosteroids may also apply if absorption occurs following topical and local use. In order to minimise the side-effects of a topical corticosteroid, it is important to apply it thinly to affected areas only, no more frequently than twice daily, and to use the least potent formulation which is fully effective.
Interactions
**Other interactions (2):**
- Co-administered drugs that can inhibit CYP3A4 (e.g.
- The extent to which this interaction is clinically relevant depends on the dose and route of administration of the corticosteroids and the potency of the CYP3A4 inhibitor.
Medicinal forms
Cream,Ointment
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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