Formulary
Clascoterone: Indications, Dosing, Side Effects and Interactions
Clascoterone is an androgen receptor inhibitor.
MedNext Academy | 3 min read
Clascoterone: Indications, Dosing, Side Effects and Interactions
Clascoterone is an androgen receptor inhibitor.
Drug action
Clascoterone is an androgen receptor inhibitor.
Indications and dose
**Acne vulgaris**
- **Child** (To The Skin): 12-17 years Apply twice daily, 1 g of cream to be applied thinly in the morning and evening.
- **Adult** (To The Skin): Apply twice daily, 1 g of cream to be applied thinly in the morning and evening.
**Acne vulgaris for clascoterone**
- **Child 12-17 years** (To the skin): Apply twice daily, 1 g of cream to be applied thinly in the morning and evening.
Cautions
Avoid contact with broken skin; avoid contact with eczematous skin; avoid contact with eyes; avoid contact with mouth; avoid contact with mucous membranes; avoid contact with sunburned skin
Side effects
Common or very common Hyperkalaemia; skin reactions; telangiectasia Rare or very rare Amenorrhoea; polycystic ovaries Frequency not known Hair colour changes; headache (in children); suppression of the hypothalamic-pituitary-adrenal axis
Interactions
**Other interactions (4):**
- Since the systemic exposure of the main component clascoterone and its metabolites following cutaneous application is negligible, no interaction with systemic treatments is expected.
- In Vitro Studies Cytochrome P450 (CYP) Enzymes: Clascoterone inhibited CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4 with an IC 50 value of >40 M.
- Clascoterone up to 50 M did not induce CYP 1A2, 2B6, or 3A4.
- Caution should be exercised in using Winlevi along other drugs known to suppress the HPA axis (e.g., topical or inhaled corticosteroids).
Pregnancy
Use with caution (limited information available). M
Breast feeding
Specialist sources indicate amounts in milk are probably low and unlikely to affect breast-fed infants due to poor absorption and high plasma-protein binding (no information available); avoid application to nipple area and direct contact with treated skin.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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