Formulary
Cholesterol: Indications, Dosing, Side Effects and Interactions
Cholesterol clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Cholesterol: Indications, Dosing, Side Effects and Interactions
Cholesterol clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Smith-Lemli-Opitz syndrome for cholesterol**
- **Neonate** (By mouth): 5-10 mg/kg 3-4 times a day.
- **Child** (By mouth): 5-10 mg/kg 3-4 times a day, doses up to 15 mg/kg 4 times daily have been used.
Interactions
**Other interactions (13):**
- The incremental low-density lipoprotein cholesterol (LDL-C) reduction due to adding Ezetimibe to colestyramine may be lessened by this interaction (see section 4.2).
- Fibrates may increase cholesterol excretion into the bile, leading to cholelithiasis.
- In animal studies, ezetimibe sometimes increased cholesterol in the gallbladder bile, but not in all species (see section 5.3).
- In a preclinical study in dogs, ezetimibe increased cholesterol in the gallbladder bile (see section 5.3).
- Using other types of laxatives or at least spacing doses is recommended.
- LIPID LOWERING MEDICINAL PRODUCTS HMG Co-A Reductase Inhibitors Atorvastatin/Efavirenz (10 mg once daily/600 mg once daily) Atorvastatin: AUC: 43% ( 34 to 50) C max : 12% ( 1 to 26)...
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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