Formulary
Cholera vaccine (inactivated): Indications, Dosing, Side Effects and Interactions
For cholera vaccine (inactivated) The inactivated cholera vaccine is an oral vaccine that contains inactivated Vibrio cholerae and recombinant cholera toxin...
MedNext Academy | 4 min read
Cholera vaccine (inactivated): Indications, Dosing, Side Effects and Interactions
For cholera vaccine (inactivated) The inactivated cholera vaccine is an oral vaccine that contains inactivated Vibrio cholerae and recombinant cholera toxin...
Drug action
For cholera vaccine (inactivated) The inactivated cholera vaccine is an oral vaccine that contains inactivated Vibrio cholerae and recombinant cholera toxin B-subunit. For information on the live vaccine, see cholera vaccine (live) .
Indications and dose
**Immunisation against cholera [primary course]**
- **Child** (By Mouth): 6-17 years 1 dose every 1-6 weeks for 2 doses, if more than 6 weeks have elapsed between doses, the primary course should be restarted, immunisation should be completed at least one week before potential exposure.
- **Adult** (By Mouth): 1 dose every 1-6 weeks for 2 doses, if more than 6 weeks have elapsed between doses, the primary course should be restarted, immunisation should be completed at least one week before potential exposure.
**Immunisation against cholera [booster dose]**
- **Child** (By Mouth): 6-17 years 1 dose, to be given within 2 years after primary course, if more than 2 years have elapsed since the last vaccination, the primary course should be repeated.
- **Adult** (By Mouth): 1 dose, to be given within 2 years after primary course, if more than 2 years have elapsed since the last vaccination, the primary course should be repeated.
**Immunisation against cholera [primary course] for cholera vaccine (inactivated)**
- **Child 2-5 years** (By mouth): 1 dose every 1-6 weeks for 3 doses, if more than 6 weeks have elapsed between doses, the primary course should be restarted, immunisation should be completed at least one week before potential exposure.
- **Child 6-17 years** (By mouth): 1 dose every 1-6 weeks for 2 doses, if more than 6 weeks have elapsed between doses, the primary course should be restarted, immunisation should be completed at least one week before potential exposure.
**Immunisation against cholera [booster dose] for cholera vaccine (inactivated)**
- **Child 2-5 years** (By mouth): 1 dose, to be given within 6 months after primary course, if more than 6 months have elapsed since the last vaccination, the primary course should be repeated.
- **Child 6-17 years** (By mouth): 1 dose, to be given within 2 years after primary course, if more than 2 years have elapsed since the last vaccination, the primary course should be repeated.
Cautions
For all vaccines, general Acute illness; minor illnesses Cautions, further information Illness UKHSA advises vaccination may be postponed if the individual is suffering from an acute illness; however, it is not necessary to postpone immunisation in patients with minor illnesses without fever or systemic upset. Predisposition to neurological problems UKHSA advises: when there is a personal or family history of febrile convulsions, there is an increased risk of these occurring during fever from any cause including immunisation, but this is not a contra-indication to immunisation. In children who have had a seizure associated with fever without neurological deterioration, immunisation is recommended ; advice on the management of fever should be given before immunisation. When a child has had a convulsion not associated with fever, and the neurological condition is not deteriorating, immunisation is recommended ; children with stable neurological disorders (e.g. spina bifida, congenital brain abnormality, and peri-natal hypoxic-ischaemic encephalopathy) should be immunised according to the recommended schedule; when there is a still evolving neurological problem , including poorly controlled epilepsy, immunisation should be deferred and the child referred to a specialist. Immunisation is recommended if a cause for the neurological disorder is identified. If a cause is not identified, immunisation should be deferred until the condition is stable. Impaired immune response and drugs affecting immune response Immune response to vaccines may be reduced in immunosuppressed patients, UKHSA advises consider seeking specialist advice.
Contraindications
For cholera vaccine (inactivated) Acute gastro-intestinal illness
Side effects
For all vaccines, general Common or very common Abdominal pain; appetite decreased; arthralgia; diarrhoea; dizziness; fatigue; fever; headache; lymphadenopathy; malaise; myalgia; nausea; skin reactions; vomiting Uncommon Hypersensitivity Side-effects For cholera vaccine (inactivated) Uncommon Gastrointestinal discomfort; gastrointestinal disorders Rare or very rare Chills; cough; dehydration; drowsiness; hyperhidrosis; increased risk of infection; insomnia; pulmonary reaction; syncope; taste altered; throat pain Frequency not known Angioedema; asthenia; dyspnoea; hypertension; influenza like illness; lymphadenitis; pain; paraesthesia; sputum increased
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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