Formulary
Chenodeoxycholic acid: Indications, Dosing, Side Effects and Interactions
Chenodeoxycholic acid clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 3 min read
Chenodeoxycholic acid: Indications, Dosing, Side Effects and Interactions
Chenodeoxycholic acid clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Cerebrotendinous xanthomatosis (specialist use only)**
- **Adult** (By Mouth): Initially 750 mg daily in 3 divided doses, increased if necessary up to 1000 mg daily in divided doses.
**Cerebrotendinous xanthomatosis (specialist use only) for chenodeoxycholic acid**
- **Child** (By mouth): Initially 5 mg/kg daily in 3 divided doses, adjusted according to response; maximum 15 mg/kg per day; maximum 1000 mg per day.
**Defective synthesis of bile acid (specialist use only) for chenodeoxycholic acid**
- **Neonate** (By mouth): Initially 5 mg/kg 3 times a day, reduced to 2.5 mg/kg 3 times a day.
- **Child** (By mouth): Initially 5 mg/kg 3 times a day, reduced to 2.5 mg/kg 3 times a day.
**Smith-Lemli-Opitz syndrome (specialist use only) for chenodeoxycholic acid**
- **Neonate** (By mouth): 7 mg/kg once daily, alternatively 7 mg/kg daily in divided doses.
- **Child** (By mouth): 7 mg/kg once daily, alternatively 7 mg/kg daily in divided doses.
Contraindications
Non-functioning gall bladder; radio-opaque stones
Side effects
Frequency not known Constipation
Pregnancy
Manufacturer advises avoid-fetotoxicity reported in animal studies.
Hepatic impairment
Manufacturer advises monitor-no information available.
Renal impairment
Manufacturer advises monitor-no information available.
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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