Formulary
Celiprolol hydrochloride: Indications, Dosing, Side Effects and Interactions
Celiprolol hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
MedNext Academy | 4 min read
Celiprolol hydrochloride: Indications, Dosing, Side Effects and Interactions
Celiprolol hydrochloride clinical drug profile including indications, dosing, side effects, cautions and interactions.
Indications and dose
**Mild to moderate hypertension**
- **Adult** (By Mouth): 200 mg once daily, dose to be taken in the morning, then increased if necessary to 400 mg once daily.
Cautions
For all beta-adrenoceptor blockers (systemic) Diabetes; first-degree AV block; history of obstructive airways disease (introduce cautiously); myasthenia gravis; portal hypertension (risk of deterioration in liver function); psoriasis; symptoms of hypoglycaemia may be masked; symptoms of thyrotoxicosis may be masked Cautions, further information Elderly Screening Tool of Older Persons' potentially inappropriate Prescriptions (STOPP) criteria to aid medication reviews (see Prescribing in the elderly for information). Potentially inappropriate: in combination with verapamil or diltiazem (risk of heart block) with bradycardia (heart rate less than 50 beats per minute), or second- or third-degree AV block (contra-indicated; risk of complete heart block, asystole) in diabetes mellitus patients with frequent hypoglycaemic episodes (risk of suppressing hypoglycaemic symptoms) if prescribed a non-selective beta-blocker (including topical beta-blockers) in a history of asthma requiring treatment (contra-indicated in asthma; risk of increased bronchospasm)
Contraindications
For all beta-adrenoceptor blockers (systemic) Asthma; cardiogenic shock; hypotension; marked bradycardia; metabolic acidosis; phaeochromocytoma (apart from specific use with alpha-blockers); Prinzmetal's angina; second-degree AV block; severe peripheral arterial disease; sick sinus syndrome; third-degree AV block; uncontrolled heart failure Contra-indications, further information Bronchospasm Beta-blockers, including those considered to be cardioselective, should usually be avoided in patients with a history of asthma, bronchospasm or a history of obstructive airways disease. However, when there is no alternative, a cardioselective beta-blocker can be given to these patients with caution and under specialist supervision. In such cases the risk of inducing bronchospasm should be appreciated and appropriate precautions taken.
Side effects
For all beta-adrenoceptor blockers (systemic) Common or very common Abdominal discomfort; bradycardia; confusion; depression; diarrhoea; dizziness; dry eye (reversible on discontinuation); dyspnoea; erectile dysfunction; fatigue; headache; heart failure; nausea; paraesthesia; peripheral coldness; rash (reversible on discontinuation); Raynaud's phenomenon; sleep disorders; syncope; visual impairment; vomiting Uncommon Alopecia; atrioventricular block; bronchospasm Rare or very rare Hallucination; psoriasis exacerbated Side-effects, further information With administration by intravenous injection, excessive bradycardia can occur and may be countered with intravenous injection of atropine sulfate. Overdose Therapeutic overdosages with beta-blockers may cause lightheadedness, dizziness, and possibly syncope as a result of bradycardia and hypotension; heart failure may be precipitated or exacerbated. With administration by intravenous injection, excessive bradycardia can occur and may be countered with intravenous injection of atropine sulfate. For details on the management of poisoning, see Beta-blockers, under Emergency treatment of poisoning . Side-effects For celiprolol hydrochloride Frequency not known Alveolitis allergic; dermatitis psoriasiform; drowsiness; hypoglycaemia masked; palpitations; thyrotoxicosis masked; tremor
Interactions
**Other interactions (22):**
- Co-administration of chlorthalidone and hydrochlorothiazide also reduces the bioavailability of celiprolol.
- Non-dihydropyridine calcium channel blockers Calcium channel antagonists such as verapamil (and to a lesser extent diltiazem) and beta-blockers both slow A-V conduction and depress myocardial...
- Floctafenine In case of shock or hypotension due to floctafenine, beta-blockers may reduce the effectiveness of drugs used to compensate these symptoms.
- Digitalis glycosides Association with beta-blockers may increase A-V conduction time.
- Fingolimod Concomitant use of fingolimod with beta-blockers may potentiate bradycardic effects and is not recommended.
- Clonidine Beta-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine.
Pregnancy
For all beta-adrenoceptor blockers (systemic) Beta-blockers may cause intra-uterine growth restriction, neonatal hypoglycaemia, and bradycardia; the risk is greater in severe hypertension.
Breast feeding
For all beta-adrenoceptor blockers (systemic) With systemic use in the mother, infants should be monitored as there is a risk of possible toxicity due to beta-blockade. However, the amount of most beta-blockers present in milk is too small to affect infants. Breast feeding For celiprolol hydrochloride Manufacturers advise avoidance.
Hepatic impairment
Manufacturer advises caution. Dose adjustments Manufacturer advises consider dose reduction.
Renal impairment
Avoid if creatinine clearance less than 15 mL/minute. M Dose adjustments Consider reducing dose by half if creatinine clearance 15-40 mL/minute. M See Prescribing in renal impairment .
Medicinal forms
Suspension
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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