Formulary
Ceftaroline fosamil: Indications, Dosing, Side Effects and Interactions
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
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Ceftaroline fosamil: Indications, Dosing, Side Effects and Interactions
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
Drug action
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
Indications and dose
**Community-acquired pneumonia**
- **Adult** (By Intravenous Infusion): 600 mg every 12 hours for 5-7 days.
**Complicated skin infections,Complicated soft-tissue infections**
- **Adult** (By Intravenous Infusion): 600 mg every 12 hours for 5-14 days, for high dose regimen consult product literature.
**Community-acquired pneumonia for ceftaroline fosamil**
- **Neonate** (By intravenous infusion): 6 mg/kg every 8 hours for 5-7 days.
- **Child up to 2 months** (By intravenous infusion): 6 mg/kg every 8 hours for 5-7 days.
- **Child 2-23 months** (By intravenous infusion): 8 mg/kg every 8 hours for 5-7 days.
- **Child 2-11 years** (By intravenous infusion): 12 mg/kg every 8 hours (max. per dose 400 mg) for 5-7 days.
- **Child 12-17 years (body-weight up to 33 kg)** (By intravenous infusion): 12 mg/kg every 8 hours (max. per dose 400 mg) for 5-7 days.
- **Child 12-17 years (body-weight 33 kg and above)** (By intravenous infusion): 600 mg every 12 hours for 5-7 days.
**Complicated skin infections, Complicated soft-tissue infections for ceftaroline fosamil**
- **Neonate** (By intravenous infusion): 6 mg/kg every 8 hours for 5-14 days.
- **Child up to 2 months** (By intravenous infusion): 6 mg/kg every 8 hours for 5-14 days.
- **Child 2-23 months** (By intravenous infusion): 8 mg/kg every 8 hours for 5-14 days, for high dose regimen consult product literature.
- **Child 2-11 years** (By intravenous infusion): 12 mg/kg every 8 hours (max. per dose 400 mg) for 5-14 days, for high dose regimen consult product literature.
- **Child 12-17 years (body-weight up to 33 kg)** (By intravenous infusion): 12 mg/kg every 8 hours (max. per dose 400 mg) for 5-14 days, for high dose regimen consult product literature.
- **Child 12-17 years (body-weight 33 kg and above)** (By intravenous infusion): 600 mg every 12 hours for 5-14 days, for high dose regimen consult product literature.
Cautions
Seizure disorders
Side effects
Common or very common Abdominal pain; diarrhoea; dizziness; eosinophilia; headache; leucopenia; nausea; neutropenia; pseudomembranous enterocolitis; skin reactions; thrombocytopenia; vomiting Uncommon Anaphylactic reaction; angioedema Rare or very rare Agranulocytosis; haemolytic anaemia; nephritis tubulointerstitial (reversible); severe cutaneous adverse reactions (SCARs) Side-effects For ceftaroline fosamil Uncommon Anaemia; Clostridioides difficile colitis; hypersensitivity Frequency not known Antibiotic associated colitis
Interactions
**Other interactions (1):**
- Ceftaroline is neither a substrate, nor an inhibitor of renal uptake transporters (OCT2, OAT1, and OAT3) in vitro .
Pregnancy
Manufacturer advises avoid unless essential-limited information; animal studies do not indicate toxicity.
Breast feeding
Manufacturer advises avoid-no information available.
Renal impairment
Dose adjustments Manufacturer advises reduce dose if creatinine clearance less than 51 mL/minute-consult product literature. See Prescribing in renal impairment .
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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