Formulary
Cefradine: Indications, Dosing, Side Effects and Interactions
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
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Cefradine: Indications, Dosing, Side Effects and Interactions
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
Drug action
Cephalosporins are antibacterials that attach to penicillin binding proteins to interrupt cell wall biosynthesis, leading to bacterial cell lysis and death.
Indications and dose
**Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria,Surgical prophylaxis**
- **Child** (By Mouth): 12-17 years 250-500 mg 4 times a day, alternatively 0.5-1 g twice daily; increased if necessary up to 1 g 4 times a day, increased dose may be used in severe infections.
- **Adult** (By Mouth): 250-500 mg 4 times a day, alternatively 0.5-1 g twice daily; increased if necessary up to 1 g 4 times a day, increased dose may be used in severe infections.
**Susceptible infections due to sensitive Gram-positive and Gram-negative bacteria, Surgical prophylaxis for cefradine**
- **Child 7-11 years** (By mouth): 25-50 mg/kg daily in 2-4 divided doses.
- **Child 12-17 years** (By mouth): 250-500 mg 4 times a day, alternatively 0.5-1 g twice daily; increased if necessary up to 1 g 4 times a day, increased dose may be used in severe infections.
**Prevention of Staphylococcus aureus lung infection in cystic fibrosis for cefradine**
- **Child 7-17 years** (By mouth): 2 g twice daily.
Side effects
Common or very common Abdominal pain; diarrhoea; dizziness; eosinophilia; headache; leucopenia; nausea; neutropenia; pseudomembranous enterocolitis; skin reactions; thrombocytopenia; vomiting Uncommon Anaphylactic reaction; angioedema Rare or very rare Agranulocytosis; haemolytic anaemia; nephritis tubulointerstitial (reversible); severe cutaneous adverse reactions (SCARs) Side-effects For cefradine Rare or very rare Antibiotic associated colitis Frequency not known Akathisia; aplastic anaemia; arthralgia; blood disorder; chest tightness; confusion; gastrointestinal discomfort; glossitis; hepatitis (transient); hypersensitivity; increased risk of infection; jaundice cholestatic; muscle tone increased; nervousness; oedema; sleep disorder
Pregnancy
Not known to be harmful.
Breast feeding
Present in milk in low concentration, but appropriate to use.
Renal impairment
Dose adjustments See Prescribing in renal impairment . In adults: Use half normal dose if creatinine clearance 5-20 mL/minute. M Use one-quarter normal dose if creatinine clearance less than 5 mL/minute. M In children: Reduce dose if creatinine clearance less than 20 mL/minute. M
Medicinal forms
Clinical governance
**Author:** MedNext Clinical Team. **Clinical reviewer:** Dr Shameer Deen, MBBS, MS, MRCS. **Sources:** BNF, Indian Pharmacopoeia, CIMS India. **Correction:** Report errors at support@mednext.academy.
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